Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.50 |
| ▸ | HTR3B | O95264 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | HTR3A | P46098 | 2/20 | 0.50 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.50 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL946093 | 1.00 | KDM4E (0.50) | KDM4ESLC6A4CYP3A4HSD17B10HTR3E | |
| SCHEMBL4573662 | 0.85 | KDM4E (0.55) | KDM4ESLC6A4CYP3A4HSD17B10HTR3E | |
| SCHEMBL947818 | 0.80 | ALDH1A1 (0.58) | SLC6A4CYP3A4HTR3EHTR3BALDH1A1 | |
| SCHEMBL947817 | 0.80 | ALDH1A1 (0.58) | SLC6A4CYP3A4HTR3EHTR3BALDH1A1 | |
| SCHEMBL6766547 | 0.79 | HTR2C (0.57) | KDM4ESLC6A4CYP3A4HSD17B10HTR3E | |
| SCHEMBL16087143 | 0.77 | KDM4E (0.57) | KDM4ESLC6A4CYP3A4HSD17B10HTR3E | |
| SCHEMBL5746436 | 0.77 | KDM4E (0.57) | KDM4ESLC6A4CYP3A4HSD17B10HTR3E | |
| SCHEMBL947810 | 0.74 | PDE10A (0.46) | PDE10AHRH3NPC1RAB9A | |
| SCHEMBL947808 | 0.74 | PDE10A (0.46) | PDE10AHRH3NPC1RAB9A | |
| SCHEMBL9010420 | 0.74 | KDM4E (0.55) | KDM4ESLC6A4CYP3A4HSD17B10HTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998962-B2 | Enantiomers of 2'-Fluoralky1-6-nitroquipazine as serotonin transporter positron emission tomography imaging agents and antidepressant therapeutics | THE UNIVERSITY OF MONTANA (US) | 2011-08-16 | — | — | US | disclosed |
| US-7998962-B2 | Enantiomers of 2'-Fluoralky1-6-nitroquipazine as serotonin transporter positron emission tomography imaging agents and antidepressant therapeutics | THE UNIVERSITY OF MONTANA (US) | 2011-08-16 | — | — | US | disclosed |
| US-7998962-B2 | Enantiomers of 2'-Fluoralky1-6-nitroquipazine as serotonin transporter positron emission tomography imaging agents and antidepressant therapeutics | THE UNIVERSITY OF MONTANA (US) | 2011-08-16 | — | — | US | disclosed |
| US-20110009419-A1 | Enantiomers of 2'-Fluoralkyl-6-nitroquipazine as Serotonin Transporter Positron Emission Tomography Imaging Agents and Antidepressant Therapeutics | GERDES JOHN M | 2011-01-13 | — | — | US | disclosed |
| US-20110009419-A1 | Enantiomers of 2'-Fluoralkyl-6-nitroquipazine as Serotonin Transporter Positron Emission Tomography Imaging Agents and Antidepressant Therapeutics | GERDES JOHN M | 2011-01-13 | — | — | US | disclosed |
| US-20110009419-A1 | Enantiomers of 2'-Fluoralkyl-6-nitroquipazine as Serotonin Transporter Positron Emission Tomography Imaging Agents and Antidepressant Therapeutics | GERDES JOHN M | 2011-01-13 | — | — | US | disclosed |
| US-7812162-B2 | Enantiomers of 2′-fluoralkyl-6-nitroquipazine as serotonin transporter positron emission tomography imaging agents and antidepressant therapeutics | THE UNIVERSITY OF MONTANA (US) | 2010-10-12 | — | — | US | disclosed |
| US-7812162-B2 | Enantiomers of 2′-fluoralkyl-6-nitroquipazine as serotonin transporter positron emission tomography imaging agents and antidepressant therapeutics | THE UNIVERSITY OF MONTANA (US) | 2010-10-12 | — | — | US | disclosed |
| US-7812162-B2 | Enantiomers of 2′-fluoralkyl-6-nitroquipazine as serotonin transporter positron emission tomography imaging agents and antidepressant therapeutics | THE UNIVERSITY OF MONTANA (US) | 2010-10-12 | — | — | US | disclosed |
| US-20080058344-A1 | Enantiomers of 2'-fluoralkyl-6-nitroquipazine as serotonin transporter positron emission tomography imaging agents and antidepressant therapeutics | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-03-06 | — | — | US | disclosed |
| US-20080058344-A1 | Enantiomers of 2'-fluoralkyl-6-nitroquipazine as serotonin transporter positron emission tomography imaging agents and antidepressant therapeutics | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-03-06 | — | — | US | disclosed |
| US-20080058344-A1 | Enantiomers of 2'-fluoralkyl-6-nitroquipazine as serotonin transporter positron emission tomography imaging agents and antidepressant therapeutics | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2008-03-06 | — | — | US | disclosed |
| WO-2007127262-A2 | ENANTIOMERS OF 2'-FLUORALKYL-6-NITROQUIPAZINE AS SEROTONIN TRANSPORTER POSITRON EMISSION TOMOGRAPHY IMAGING AGENTS AND ANTIDEPRESSANT THERAPEUTICS | THE UNIVERSITY OF MONTANA (US) | 2007-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009419-A1 | Enantiomers of 2'-Fluoralkyl-6-nitroquipazine as Serotonin Transporter Positron Emission Tomography Imaging Agents and Antidepressant Therapeutics | SLC6A4, SLC18A2, HTR6 | KDM4E 3955/4885SLC6A4 1/4885CYP3A4 333/4885 |
| US-20080058344-A1 | Enantiomers of 2'-fluoralkyl-6-nitroquipazine as serotonin transporter positron emission tomography imaging agents and antidepressant therapeutics | SLC6A4, SLC18A2, HTR3A | KDM4E 3879/4885SLC6A4 1/4885CYP3A4 381/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.