Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 4/20 | 0.60 |
| ▸ | CA12 | O43570 | 7/20 | 0.56 |
| ▸ | CA1 | P00915 | 7/20 | 0.56 |
| ▸ | CA7 | P43166 | 7/20 | 0.56 |
| ▸ | CA9 | Q16790 | 7/20 | 0.56 |
| ▸ | CA13 | Q8N1Q1 | 6/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TYR | P14679 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Luvangetin SCHEMBL14511557 | 0.83 | PDE4D (0.62) | PDE4DCA12CA1CA7CA9 | |
| SCHEMBL9464016 | 0.78 | KDM4E (0.44) | PDE4DCA12CA1CA7CA9 | |
| SCHEMBL30273160 | 0.75 | PDE4D (1.00) | PDE4DCA12CA1CA7CA9 | |
| SCHEMBL25619757 | 0.75 | PDE4D (1.00) | PDE4DCA12CA1CA7CA9 | |
| SCHEMBL30273157 | 0.75 | PDE4D (1.00) | PDE4DCA12CA1CA7CA9 | |
| SCHEMBL30589491 | 0.72 | PDE4D (1.00) | PDE4DCA12CA1CA7CA9 | |
| Xanthyletin SCHEMBL2120500 | 0.71 | CA12 (1.00) | PDE4DCA12CA1CA7CA9 | |
| SCHEMBL5773063 | 0.69 | ALDH1A1 (0.43) | PDE4DALDH1A1HPGDCYP3A4TYR | |
| Sesalin SCHEMBL29402981 | 0.69 | PDE4D (0.63) | PDE4DCA12CA1CA7CA9 | |
| Sesalin SCHEMBL8993385 | 0.69 | PDE4D (0.63) | PDE4DCA12CA1CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5216176-A | 7-alkoxycoumarins, dihydropsoralens, and benzodipyranones as photo-activated therapeutic agents and inhibitors of epidermal growth factor | LEHIGH UNIVERSITY (US) | 1993-06-01 | — | — | US | disclosed |
| WO-1990008529-A2 | 7-ALKOXYCOUMARINS, DIHYDROPSORALENS, AND BENZODIPYRANONES AS PHOTO-ACTIVATED THERAPEUTIC AGENTS AND INHIBITORS OF EPIDERMAL GROWTH FACTOR | LEHIGH UNIVERSITY (US) | 1990-08-09 | — | — | WO | disclosed |