Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 4/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 5/20 | 0.55 |
| ▸ | CA12 | O43570 | 4/20 | 0.55 |
| ▸ | CA1 | P00915 | 4/20 | 0.55 |
| ▸ | CA7 | P43166 | 4/20 | 0.55 |
| ▸ | CA9 | Q16790 | 4/20 | 0.55 |
| ▸ | CA13 | Q8N1Q1 | 3/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sesalin SCHEMBL29402981 | 1.00 | PDE4D (0.63) | PDE4DKDM4EALDH1A1TSHRMEN1 | |
| SCHEMBL30273157 | 0.78 | PDE4D (1.00) | PDE4DKDM4EALDH1A1MEN1GLA | |
| SCHEMBL30273160 | 0.78 | PDE4D (1.00) | PDE4DKDM4EALDH1A1MEN1GLA | |
| SCHEMBL31238044 | 0.77 | PDE4D (0.69) | PDE4DKDM4EALDH1A1HPGDCA12 | |
| SCHEMBL24728304 | 0.76 | PDE4D (0.48) | PDE4DKDM4EALDH1A1HPGDCA12 | |
| SCHEMBL24728286 | 0.75 | PDE4D (0.50) | PDE4DALDH1A1HPGDCYP3A4PTPN1 | |
| SCHEMBL31237832 | 0.75 | PDE4D (1.00) | PDE4DKDM4EALDH1A1HPGDCA12 | |
| SCHEMBL30589491 | 0.75 | PDE4D (1.00) | PDE4DKDM4EALDH1A1TSHRMEN1 | |
| Kanzonol W SCHEMBL29378682 | 0.72 | TYR (0.65) | PDE4DPTPN1 | |
| Dipetalolactone SCHEMBL29489962 | 0.72 | CA12 (0.61) | PDE4DKDM4EALDH1A1TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10906033-B2 | Synthesis and application of chiral substituted polyvinylpyrrolidinones | KANSAS STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2021-02-02 | — | — | US | disclosed |
| US-20200306737-A1 | SYNTHESIS AND APPLICATION OF CHIRAL SUBSTITUTED POLYVINYLPYRROLIDINONES | KANSAS STATE UNIVERSITY RESEARCH FOUNDATION | 2020-10-01 | — | — | US | disclosed |
| WO-2017172763-A1 | SYNTHESIS AND APPLICATION OF CHIRAL SUBSTITUTED POLYVINYLPYRROLIDINONES | KANSAS STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2017-10-05 | — | — | WO | disclosed |
| EP-2001463-B1 | A PHARMACEUTICAL COMPOSITION USEFUL AS ACETYL CHOLINESTERASE INHIBITORS | COUNCIL SCIENT IND RES (IN) | 2013-07-03 | — | — | EP | disclosed |
| US-20120277297-A1 | Pharmaceutical Composition Useful as Acetylcholinesterase Inhibitors | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2012-11-01 | — | — | US | disclosed |
| US-20120277297-A1 | Pharmaceutical Composition Useful as Acetylcholinesterase Inhibitors | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2012-11-01 | — | — | US | disclosed |
| US-8188143-B2 | Pharmaceutical composition useful as acetylcholinesterase inhibitors | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2012-05-29 | — | — | US | disclosed |
| US-8188143-B2 | Pharmaceutical composition useful as acetylcholinesterase inhibitors | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2012-05-29 | — | — | US | disclosed |
| US-20080009544-A1 | Pharmaceutical Composition Useful as Acetylcholinesterase Inhibitors | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2008-01-10 | — | — | US | disclosed |
| US-20080009544-A1 | Pharmaceutical Composition Useful as Acetylcholinesterase Inhibitors | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2008-01-10 | — | — | US | disclosed |
| WO-2007107846-A1 | A PHARMACEUTICAL COMPOSITION USEFUL AS ACETYL CHOLINESTERASE INHIBITORS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2007-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080009544-A1 | Pharmaceutical Composition Useful as Acetylcholinesterase Inhibitors | ACHE, BCHE, CHRNB1 | PDE4D 573/4885KDM4E 1482/4885ALDH1A1 1025/4885 |
| US-20200306737-A1 | SYNTHESIS AND APPLICATION OF CHIRAL SUBSTITUTED POLYVINYLPYRROLIDINONES | POLRMT, CNBP, DHPS | PDE4D 3542/4885KDM4E 1265/4885ALDH1A1 626/4885 |
| US-10906033-B2 | Synthesis and application of chiral substituted polyvinylpyrrolidinones | POLRMT, CNBP, DHPS | PDE4D 3542/4885KDM4E 1265/4885ALDH1A1 626/4885 |
| US-20120277297-A1 | Pharmaceutical Composition Useful as Acetylcholinesterase Inhibitors | ACHE, BCHE, CYP3A7 | PDE4D 467/4885KDM4E 1461/4885ALDH1A1 547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.