Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 4/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.61 |
| ▸ | GMNN | O75496 | 3/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.61 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.61 |
| ▸ | BLM | P54132 | 2/20 | 0.61 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.61 |
| ▸ | GLA | P06280 | 1/20 | 0.61 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12137165 | 0.98 | LMNA (0.64) | LMNASMN1; SMN2MAPK1MAPTMEN1 | |
| Bromide SCHEMBL6143111 | 0.97 | LMNA (0.62) | LMNASMN1; SMN2MAPK1MAPTMEN1 | |
| SCHEMBL19923321 | 0.86 | LMNA (0.62) | LMNASMN1; SMN2MAPK1MAPTMEN1 | |
| SCHEMBL20742884 | 0.86 | LMNA (0.62) | LMNASMN1; SMN2MAPK1MAPTMEN1 | |
| SCHEMBL19923320 | 0.86 | LMNA (0.62) | LMNASMN1; SMN2MAPK1MAPTMEN1 | |
| SCHEMBL28916570 | 0.86 | LMNA (0.62) | LMNASMN1; SMN2MAPK1MAPTMEN1 | |
| SCHEMBL28290850 | 0.86 | LMNA (0.62) | LMNASMN1; SMN2MAPK1MAPTMEN1 | |
| SCHEMBL3193491 | 0.84 | LMNA (0.64) | LMNASMN1; SMN2MAPK1MAPTMEN1 | |
| Levocarnitine Propionate SCHEMBL2638847 | 0.84 | MEN1 (0.70) | LMNASMN1; SMN2MAPK1MAPTMEN1 | |
| Levocarnitine Propionate SCHEMBL1650830 | 0.84 | MEN1 (0.70) | LMNASMN1; SMN2MAPK1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-5097785-A | — | — | None | — | — | JP | disclosed |
| JP-H0597785-A | ESTER OF (R)(-)-CARNITINE AND ACYL-(R)(-)-CARNITINE WITH BETA-HYDROXYBUTYRIC ACID | SIGMA TAU IND FARMACEUT RIUNITE SPA | 1993-04-20 | — | — | JP | disclosed |