Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | FABP4 | P15090 | 2/20 | 0.40 |
| ▸ | FABP3 | P05413 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9464891 | 0.90 | FABP4 (0.41) | KDM4EFABP4FABP3ALDH1A1HSD17B10 | |
| SCHEMBL9520939 | 0.81 | KDM4E (0.39) | KDM4EFABP4FABP3ALDH1A1HPGD | |
| SCHEMBL29948201 | 0.76 | SSTR4 (0.41) | ALDH1A1PTGDR2 | |
| SCHEMBL30207743 | 0.76 | SSTR4 (0.41) | ALDH1A1PTGDR2 | |
| SCHEMBL5847643 | 0.76 | SSTR4 (0.41) | ALDH1A1PTGDR2 | |
| SCHEMBL769058 | 0.76 | SSTR4 (0.41) | ALDH1A1PTGDR2 | |
| SCHEMBL5847641 | 0.76 | SSTR4 (0.41) | ALDH1A1PTGDR2 | |
| SCHEMBL11002902 | 0.75 | MAOA (0.45) | PTGDR2 | |
| SCHEMBL20480108 | 0.75 | ADRA2A (0.47) | FABP4FABP3PTGDR2 | |
| SCHEMBL2729875 | 0.75 | ADRA2A (0.47) | KDM4EALDH1A1PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5185364-A | Selectively inhibit alpha-2-adrenergic receptors | ABBOTT LABORATORIES (US) | 1993-02-09 | — | — | US | disclosed |
| US-5140039-A | Antidepressants, metabolic disorders | ABBOTT LABORATORIES (US) | 1992-08-18 | — | — | US | disclosed |
| US-5089519-A | Antidepressants; antagonists for alpha-2-adrenergic receptors | ABBOTT LABORATORIES (US) | 1992-02-18 | — | — | US | disclosed |
| EP-0396620-A4 | AMINOMETHYL-CHROMAN AND -THIOCHROMAN COMPOUNDS | — | 1991-01-23 | — | — | EP | disclosed |
| EP-0396620-A1 | AMINOMETHYL-CHROMAN AND -THIOCHROMAN COMPOUNDS. | ABBOTT LAB (US) | 1990-11-14 | — | — | EP | disclosed |
| EP-0325964-A1 | Aminomethyl-chroman and -thiochroman compounds | ABBOTT LABORATORIES (US) | 1989-08-02 | — | — | EP | disclosed |
| WO-1989006534-A1 | AMINOMETHYL-CHROMAN AND -THIOCHROMAN COMPOUNDS | ABBOTT LABORATORIES (US) | 1989-07-27 | — | — | WO | disclosed |