Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 13/20 | 0.54 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.54 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.54 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9466272 | 0.89 | OPRM1 (0.54) | OPRM1OPRD1OPRK1CACNA1C | |
| SCHEMBL9780089 | 0.87 | OPRM1 (0.71) | OPRM1OPRD1OPRK1CACNA1C | |
| SCHEMBL9466239 | 0.86 | OPRM1 (0.41) | OPRM1OPRD1OPRK1CACNA1C | |
| SCHEMBL9780091 | 0.85 | OPRM1 (0.54) | OPRM1OPRD1OPRK1 | |
| SCHEMBL9467323 | 0.83 | OPRD1 (0.77) | OPRM1OPRD1OPRK1CACNA1C | |
| SCHEMBL9466400 | 0.81 | OPRD1 (0.56) | OPRM1OPRD1OPRK1CACNA1C | |
| SCHEMBL6850215 | 0.75 | OPRM1 (0.45) | OPRM1OPRD1OPRK1CACNA1C | |
| SCHEMBL9466393 | 0.73 | DRD2 (0.41) | OPRM1OPRD1OPRK1CACNA1C | |
| SCHEMBL9473188 | 0.73 | OPRM1 (0.71) | OPRM1OPRD1OPRK1 | |
| SCHEMBL23805134 | 0.73 | OPRM1 (0.78) | OPRM1OPRD1OPRK1CACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0396282-A2 | N-aryl-N-[4-(heterocyclicalkyl) piperidinyl]amides and pharmaceutical compositions and methods employing such compounds | BOC, INC. (US) | 1990-11-07 | — | — | EP | claimed |
| US-RE34201-E | Analgesics | ANAQUEST, INC. (US) | 1993-03-23 | — | — | US | disclosed |
| US-5053411-A | Analgesics | ANAQUEST, INC. (US) | 1991-10-01 | — | — | US | disclosed |
| EP-0396282-A2 | N-aryl-N-[4-(heterocyclicalkyl) piperidinyl]amides and pharmaceutical compositions and methods employing such compounds | BOC, INC. (US) | 1990-11-07 | — | — | EP | disclosed |