Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA4 | P22459 | 1/20 | 0.35 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.31 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9466553 | 0.81 | HIF1A (0.33) | KCNA4KCNA1KDM4EALDH1A1DRD2 | |
| SCHEMBL12989481 | 0.81 | KCNA4 (0.36) | KCNA4KCNA1KDM4EALDH1A1DRD2 | |
| SCHEMBL7150031 | 0.73 | HDAC3 (0.54) | KDM4E | |
| SCHEMBL7152545 | 0.70 | MAP2K1 (0.48) | KCNA4 | |
| SCHEMBL14163702 | 0.70 | KDM4E (0.68) | KDM4EALDH1A1DRD2DRD3HSD17B10 | |
| SCHEMBL645360 | 0.69 | KDM4E (0.41) | KDM4EALDH1A1HSD17B10ALOX15HIF1A | |
| SCHEMBL9625733 | 0.68 | EPHX2 (0.51) | ALDH1A1 | |
| SCHEMBL28007671 | 0.67 | LMNA (0.62) | — | |
| SCHEMBL6539681 | 0.66 | LMNA (0.51) | ALDH1A1 | |
| SCHEMBL11953188 | 0.66 | TSHR (0.45) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5272253-A | Cluster conjugates of drugs with antibodies | ELI LILLY AND COMPANY (US) | 1993-12-21 | — | — | US | disclosed |
| EP-0525992-A2 | Cluster conjugates of drugs with antibodies | ELI LILLY AND COMPANY (US) | 1993-02-03 | — | — | EP | disclosed |
| US-5094849-A | Antitumor | ELI LILLY AND COMPANY (US) | 1992-03-10 | — | — | US | disclosed |
| US-5006652-A | Intermediates for antibody-vinca drug conjugates | ELI LILLY AND COMPANY (US) | 1991-04-09 | — | — | US | disclosed |
| EP-0354728-A2 | Cytotoxic drug conjugates | ELI LILLY AND COMPANY (US) | 1990-02-14 | — | — | EP | disclosed |