Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | CMA1 | P23946 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9468974 | 0.85 | MAPT (0.45) | MAPTKMT2AMEN1ALDH1A1HPGD | |
| SCHEMBL1229759 | 0.74 | HTR2C (0.43) | MAPTKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL1647137 | 0.70 | KCNN4 (0.42) | MAPTKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL18839845 | 0.69 | HCAR3 (0.40) | MAPTKMT2AMEN1ALDH1A1KDM4E | |
| Acetic Acid SCHEMBL28608130 | 0.67 | MAPT (0.56) | MAPTKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL9469693 | 0.67 | KDM4E (0.46) | MAPTKMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL9618797 | 0.66 | MAPT (0.54) | MAPTKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL1236135 | 0.65 | TP53 (0.35) | MAPTALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL828870 | 0.65 | HCAR3 (0.39) | MAPTALDH1A1KDM4EHPGDGAA | |
| SCHEMBL874198 | 0.64 | ALDH1A1 (0.61) | MAPTKMT2AMEN1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5252592-A | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1993-10-12 | — | — | US | disclosed |
| EP-0495526-A1 | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1992-07-22 | — | — | EP | disclosed |