Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | PPARG | P37231 | 5/20 | 0.43 |
| ▸ | PPARA | Q07869 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9690023 | 0.80 | KDM4E (0.38) | KDM4EALDH1A1HPGDKMT2AGAA | |
| SCHEMBL9688895 | 0.79 | KDM4E (0.43) | KDM4EALDH1A1HPGDKMT2APRNP | |
| SCHEMBL9690579 | 0.75 | KDM4E (0.45) | KDM4EALDH1A1HPGDKMT2AMAPT | |
| SCHEMBL9689439 | 0.75 | KDM4E (0.45) | KDM4EALDH1A1HPGDKMT2AMAPT | |
| SCHEMBL9688900 | 0.73 | KDM4E (0.41) | KDM4EALDH1A1HPGDALOX5GAA | |
| SCHEMBL9690027 | 0.73 | HDAC6 (0.38) | KDM4EALDH1A1KMT2AGAARAB9A | |
| SCHEMBL9689433 | 0.73 | ALDH1A1 (0.49) | KDM4EALDH1A1HPGDKMT2AMAPT | |
| SCHEMBL9688569 | 0.73 | KDM4E (0.43) | KDM4EALDH1A1HPGDKMT2AMAPT | |
| SCHEMBL9695863 | 0.73 | GSK3B (0.45) | KDM4EALDH1A1HPGDHTR2CMAPT | |
| SCHEMBL9469700 | 0.73 | ALDH1A1 (0.51) | KDM4EALDH1A1HPGDKMT2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5252592-A | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1993-10-12 | — | — | US | disclosed |
| EP-0495526-A1 | Tetrazoleacetic acid derivatives having aldose reductase inhibitory activity | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1992-07-22 | — | — | EP | disclosed |