Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.64 |
| ▸ | RAB9A | P51151 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | ITK | Q08881 | 2/20 | 0.53 |
| ▸ | AXL | P30530 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9469075 | 0.82 | KDM4E (0.61) | KDM4EMAPTRAB9AMEN1KMT2A | |
| SCHEMBL6118322 | 0.82 | RAB9A (0.64) | KDM4EMAPTRAB9AMEN1KMT2A | |
| SCHEMBL903536 | 0.82 | FLT3 (0.53) | KDM4EMAPTRAB9AMEN1KMT2A | |
| SCHEMBL28763455 | 0.80 | KDM4E (0.57) | KDM4EMAPTRAB9AMEN1KMT2A | |
| SCHEMBL6303491 | 0.80 | KDM4E (0.61) | KDM4EMAPTRAB9AMEN1KMT2A | |
| SCHEMBL7066063 | 0.79 | MEN1 (0.59) | KDM4EMAPTRAB9AMEN1KMT2A | |
| SCHEMBL1429201 | 0.78 | NPC1 (1.00) | KDM4EMAPTRAB9AMEN1KMT2A | |
| SCHEMBL25175575 | 0.78 | KDM4E (0.62) | KDM4EMAPTRAB9AMEN1KMT2A | |
| SCHEMBL29361867 | 0.77 | KDR (0.58) | KDM4EMAPTRAB9AMEN1KMT2A | |
| SCHEMBL221259 | 0.77 | KDR (0.58) | KDM4EMAPTRAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166170-A | 2-(AMINOARYL) INDOLES AND INDOLINES AS TOPICAL ANTIINFLAMMATORY AGENTS FOR THE TREATMENT OF SKIN DISORDERS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-11-24 | — | — | US | claimed |
| US-5214059-A | Dermatitis, psoriasis | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-05-25 | — | — | US | disclosed |
| US-5166170-A | 2-(AMINOARYL) INDOLES AND INDOLINES AS TOPICAL ANTIINFLAMMATORY AGENTS FOR THE TREATMENT OF SKIN DISORDERS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-11-24 | — | — | US | disclosed |
| EP-0406734-A2 | 2-(Aminoaryl)indoles and indolines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-01-09 | — | — | EP | disclosed |