Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 4/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | FBP1 | P09467 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9469201 | 0.82 | MAPT (0.43) | HTR5AHTR1AHTR2CHTR7HTR1D | |
| SCHEMBL9469811 | 0.78 | AR (0.47) | HTR2CHTR2AMAPTKDM1ARAB9A | |
| SCHEMBL9469797 | 0.67 | AR (0.47) | MAPTMEN1KMT2A | |
| SCHEMBL11170515 | 0.64 | BRD4 (0.44) | HTR5AHTR1AHTR2CHTR7HTR1D | |
| SCHEMBL9469027 | 0.62 | HTR3E (0.39) | HTR5AHTR3AMAPTMEN1KMT2A | |
| SCHEMBL9469090 | 0.61 | AR (0.47) | HTR2AMAPTMEN1KMT2ARAB9A | |
| SCHEMBL31586961 | 0.61 | NOS3 (0.43) | HTR2CHTR7HTR2AMAPTMEN1 | |
| SCHEMBL20392762 | 0.61 | NOS3 (0.43) | HTR2CHTR7HTR2AMAPTMEN1 | |
| SCHEMBL12826365 | 0.60 | MAPT (0.42) | MAPTEPAS1MEN1NPC1KMT2A | |
| SCHEMBL160438 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166170-A | 2-(AMINOARYL) INDOLES AND INDOLINES AS TOPICAL ANTIINFLAMMATORY AGENTS FOR THE TREATMENT OF SKIN DISORDERS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-11-24 | — | — | US | claimed |
| US-5214059-A | Dermatitis, psoriasis | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-05-25 | — | — | US | disclosed |
| US-5166170-A | 2-(AMINOARYL) INDOLES AND INDOLINES AS TOPICAL ANTIINFLAMMATORY AGENTS FOR THE TREATMENT OF SKIN DISORDERS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-11-24 | — | — | US | disclosed |
| EP-0406734-A2 | 2-(Aminoaryl)indoles and indolines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-01-09 | — | — | EP | disclosed |