Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 13/20 | 0.58 |
| ▸ | ELANE | P08246 | 2/20 | 0.57 |
| ▸ | MARK3 | P27448 | 1/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9470463 | 0.89 | PGR (0.46) | PGRELANEMARK3EGLN1 | |
| SCHEMBL9981596 | 0.87 | PGR (0.57) | PGRELANEMARK3EGLN1HPGD | |
| SCHEMBL9469392 | 0.87 | PGR (0.56) | PGRELANEMARK3EGLN1ALDH1A1 | |
| SCHEMBL9469933 | 0.86 | PGR (0.60) | PGRELANEMARK3MAPTHPGD | |
| SCHEMBL9469726 | 0.86 | KMT2A (0.45) | PGRELANEMARK3EGLN1ALDH1A1 | |
| SCHEMBL9469799 | 0.86 | PGR (0.58) | PGRMARK3EGLN1MAPTHPGD | |
| SCHEMBL9469382 | 0.86 | PGR (0.43) | PGRELANEMARK3EGLN1MAPT | |
| SCHEMBL9981591 | 0.86 | PGR (0.43) | PGRELANEMARK3EGLN1 | |
| SCHEMBL1699202 | 0.86 | PGR (0.43) | PGRELANEMARK3EGLN1MAPT | |
| SCHEMBL9470419 | 0.85 | PGR (0.43) | PGRELANEMARK3MAPTKAT2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5182289-A | Pyrrolo 2,3-b!Pyridin-2-one Derivatives | SCHERING CORPORATION (US) | 1993-01-26 | — | — | US | claimed |
| EP-0419561-A1 | HETEROBICYCLIC COMPOUNDS HAVING ANTIINFLAMMATORY ACTIVITY | SCHERING CORPORATION (US) | 1991-04-03 | — | — | EP | claimed |
| WO-1989012637-A1 | HETEROBICYCLIC COMPOUNDS HAVING ANTIINFLAMMATORY ACTIVITY | SCHERING CORPORATION (US) | 1989-12-28 | — | — | WO | claimed |
| US-5182289-A | Pyrrolo 2,3-b!Pyridin-2-one Derivatives | SCHERING CORPORATION (US) | 1993-01-26 | — | — | US | disclosed |
| EP-0419561-A1 | HETEROBICYCLIC COMPOUNDS HAVING ANTIINFLAMMATORY ACTIVITY | SCHERING CORPORATION (US) | 1991-04-03 | — | — | EP | disclosed |
| WO-1989012637-A1 | HETEROBICYCLIC COMPOUNDS HAVING ANTIINFLAMMATORY ACTIVITY | SCHERING CORPORATION (US) | 1989-12-28 | — | — | WO | disclosed |
| EP-0347698-A1 | Heterobicyclic compounds having antiinflammatory activity | SCHERING CORPORATION (US) | 1989-12-27 | — | — | EP | disclosed |