Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 7/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | MARK3 | P27448 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9469711 | 0.86 | PGR (0.58) | ALDH1A1PGRMARK3ELANEEGLN1 | |
| SCHEMBL9981596 | 0.85 | PGR (0.57) | ALDH1A1PGRMGLLMARK3ELANE | |
| SCHEMBL9469392 | 0.84 | PGR (0.56) | KMT2AMEN1ALDH1A1PGRMARK3 | |
| SCHEMBL9469799 | 0.83 | PGR (0.58) | KMT2AMEN1PGRMARK3EGLN1 | |
| SCHEMBL9469382 | 0.83 | PGR (0.43) | NPC1ALDH1A1RAB9ASMN1; SMN2PGR | |
| SCHEMBL1699202 | 0.83 | PGR (0.43) | KMT2APGRMGLLMARK3ELANE | |
| SCHEMBL9981591 | 0.83 | PGR (0.43) | KMT2AMEN1PGRMARK3ELANE | |
| SCHEMBL9469970 | 0.81 | PGR (0.60) | KMT2AMEN1ALDH1A1RAB9APGR | |
| SCHEMBL9469981 | 0.81 | PGR (0.41) | NPC1RAB9APGRMARK3ELANE | |
| SCHEMBL9470463 | 0.81 | PGR (0.46) | PGRMARK3ELANEEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5182289-A | Pyrrolo 2,3-b!Pyridin-2-one Derivatives | SCHERING CORPORATION (US) | 1993-01-26 | — | — | US | claimed |
| EP-0419561-A1 | HETEROBICYCLIC COMPOUNDS HAVING ANTIINFLAMMATORY ACTIVITY | SCHERING CORPORATION (US) | 1991-04-03 | — | — | EP | claimed |
| WO-1989012637-A1 | HETEROBICYCLIC COMPOUNDS HAVING ANTIINFLAMMATORY ACTIVITY | SCHERING CORPORATION (US) | 1989-12-28 | — | — | WO | claimed |
| EP-0347698-A1 | Heterobicyclic compounds having antiinflammatory activity | SCHERING CORPORATION (US) | 1989-12-27 | — | — | EP | claimed |