Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 7/20 | 0.46 |
| ▸ | ITGAL | P20701 | 6/20 | 0.43 |
| ▸ | ITGB2 | P05107 | 5/20 | 0.43 |
| ▸ | ICAM1 | P05362 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.40 |
| ▸ | MARK3 | P27448 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9469933 | 0.89 | PGR (0.60) | PGRELANECRHR1MARK3 | |
| SCHEMBL9469711 | 0.89 | PGR (0.58) | PGRELANEMARK3EGLN1 | |
| SCHEMBL9470419 | 0.85 | PGR (0.43) | PGRELANEMARK3 | |
| SCHEMBL9469392 | 0.84 | PGR (0.56) | PGRELANEMARK3EGLN1 | |
| SCHEMBL9469763 | 0.81 | PGR (0.44) | PGRELANECRHR1 | |
| SCHEMBL9981596 | 0.81 | PGR (0.57) | PGRELANEMARK3EGLN1 | |
| SCHEMBL9469726 | 0.81 | KMT2A (0.45) | PGRELANEMARK3EGLN1 | |
| SCHEMBL9469799 | 0.80 | PGR (0.58) | PGRTSHRMARK3EGLN1 | |
| SCHEMBL1699202 | 0.80 | PGR (0.43) | PGRELANEMARK3EGLN1 | |
| SCHEMBL9469382 | 0.80 | PGR (0.43) | PGRTSHRELANEMARK3EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5182289-A | Pyrrolo 2,3-b!Pyridin-2-one Derivatives | SCHERING CORPORATION (US) | 1993-01-26 | — | — | US | claimed |
| EP-0419561-A1 | HETEROBICYCLIC COMPOUNDS HAVING ANTIINFLAMMATORY ACTIVITY | SCHERING CORPORATION (US) | 1991-04-03 | — | — | EP | claimed |
| WO-1989012637-A1 | HETEROBICYCLIC COMPOUNDS HAVING ANTIINFLAMMATORY ACTIVITY | SCHERING CORPORATION (US) | 1989-12-28 | — | — | WO | claimed |