Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.66 |
| ▸ | DRD3 | P35462 | 4/20 | 0.66 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.66 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.66 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.66 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.66 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.66 |
| ▸ | DRD1 | P21728 | 1/20 | 0.66 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.66 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.66 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.66 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.57 |
| ▸ | HTR7 | P34969 | 6/20 | 0.53 |
| ▸ | DRD2 | P14416 | 5/20 | 0.52 |
| ▸ | HTR2A | P28223 | 4/20 | 0.52 |
| ▸ | DRD5 | P21918 | 3/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.52 |
| ▸ | HTR6 | P50406 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9470983 | 0.95 | DRD3 (0.60) | HTR1ADRD3ADRA1AABCB11ADRA2A | |
| SCHEMBL9471043 | 0.91 | HTR1A (0.58) | HTR1ADRD3ADRA1AABCB11ADRA2A | |
| SCHEMBL9470678 | 0.85 | DRD3 (0.55) | HTR1ADRD3ADRA1AABCB11ADRA2A | |
| SCHEMBL9471074 | 0.84 | HTR7 (0.65) | HTR1ADRD3KCNH2HTR7 | |
| SCHEMBL5654034 | 0.83 | HTR1A (0.66) | HTR1ADRD3ADRA1AABCB11ADRA2A | |
| SCHEMBL11929304 | 0.81 | HTR1A (0.67) | HTR1ADRD3ADRA1AABCB11ADRA2A | |
| SCHEMBL2527416 | 0.80 | HTR1A (0.66) | HTR1ADRD3ADRA1AABCB11ADRA2A | |
| SCHEMBL2526228 | 0.80 | HTR1A (0.66) | HTR1ADRD3ADRA1AABCB11ADRA2A | |
| Flibanserin SCHEMBL29399513 | 0.80 | HTR1A (1.00) | HTR1ADRD3ADRA1AABCB11ADRA2A | |
| Flibanserin SCHEMBL30249132 | 0.80 | HTR1A (1.00) | HTR1ADRD3ADRA1AABCB11ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5246951-A | Nonsteroidal antiinflammatory agents | ADIR ET COMPAGNIE (FR) | 1993-09-21 | — | — | US | disclosed |
| EP-0487423-A1 | Benzoselenazolinone derivatives, their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1992-05-27 | — | — | EP | disclosed |