Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.66 |
| ▸ | DRD3 | P35462 | 6/20 | 0.66 |
| ▸ | DRD1 | P21728 | 3/20 | 0.66 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.66 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.66 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.66 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.66 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.66 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.66 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.66 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.66 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.57 |
| ▸ | HTR7 | P34969 | 6/20 | 0.53 |
| ▸ | DRD2 | P14416 | 5/20 | 0.52 |
| ▸ | HTR2A | P28223 | 4/20 | 0.52 |
| ▸ | DRD5 | P21918 | 3/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.52 |
| ▸ | HTR6 | P50406 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11929304 | 0.88 | HTR1A (0.67) | HTR1ADRD3DRD1ADRA1AABCB11 | |
| SCHEMBL2526228 | 0.87 | HTR1A (0.66) | HTR1ADRD3DRD1ADRA1AABCB11 | |
| SCHEMBL2527416 | 0.87 | HTR1A (0.66) | HTR1ADRD3DRD1ADRA1AABCB11 | |
| SCHEMBL21669283 | 0.85 | HTR1A (0.67) | HTR1ADRD3DRD1ADRA1AABCB11 | |
| SCHEMBL7056301 | 0.84 | HTR1A (0.63) | HTR1ADRD3DRD1ADRA1AABCB11 | |
| SCHEMBL11925192 | 0.84 | HTR1A (0.63) | HTR1ADRD3DRD1ADRA1AABCB11 | |
| SCHEMBL9470225 | 0.83 | HTR1A (0.66) | HTR1ADRD3DRD1ADRA1AABCB11 | |
| SCHEMBL21669397 | 0.83 | HTR1A (0.61) | HTR1ADRD3DRD1ADRA1AABCB11 | |
| SCHEMBL8125860 | 0.82 | HTR7 (0.62) | HTR1ADRD3DRD1ADRA1AABCB11 | |
| SCHEMBL21669406 | 0.81 | HTR1A (0.70) | HTR1ADRD3DRD1ADRA1AABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070032654-A1 | 1-(2-(4-(3-trifluoromethyl-phenyl)piperazin-1-yl) ethyl)-2,3-dihydro-1H-benzimidazol-2-one (flibanserin); useful for treating psychological and nervous system disorders; prepared by heating a benzimidazolone compound with a piperazine derivative | BIDACHEM SPA (IT) | 2007-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032654-A1 | 1-(2-(4-(3-trifluoromethyl-phenyl)piperazin-1-yl) ethyl)-2,3-dihydro-1H-benzimidazol-2-one (flibanserin); useful for treating psychological and nervous system disorders; prepared by heating a benzimidazolone compound with a piperazine derivative | HTR1B, HTR3A, HTR5A | HTR1A 4/4885DRD3 70/4885DRD1 77/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.