Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR4 | O00206 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | DNTT | P04053 | 2/20 | 0.36 |
| ▸ | POLA1 | P09884 | 2/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10401319 | 0.85 | ALDH1A1 (0.42) | TLR4ALDH1A1POLBL3MBTL1MEN1 | |
| SCHEMBL9753067 | 0.82 | MEN1 (0.50) | TLR4ALDH1A1POLBL3MBTL1MEN1 | |
| SCHEMBL20103471 | 0.81 | TLR4 (0.43) | TLR4ALDH1A1POLBL3MBTL1MEN1 | |
| SCHEMBL17118109 | 0.79 | TLR4 (0.49) | TLR4ALDH1A1POLBL3MBTL1MEN1 | |
| SCHEMBL1141761 | 0.79 | TLR4 (0.49) | TLR4ALDH1A1POLBL3MBTL1MEN1 | |
| SCHEMBL7633659 | 0.71 | MEN1 (0.46) | TLR4ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL7634605 | 0.71 | CHRM2 (0.50) | TLR4ALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL1134463 | 0.70 | ALDH1A1 (0.53) | TLR4ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL1536082 | 0.70 | ALDH1A1 (0.50) | TLR4ALDH1A1POLBL3MBTL1MEN1 | |
| SCHEMBL7638589 | 0.69 | TLR4 (0.41) | TLR4ALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5192800-A | Hypotensive agents | PFIZER INC. (US) | 1993-03-09 | — | — | US | disclosed |
| US-5030654-A | Glutaramide diuretic agents | PFIZER INC. (US) | 1991-07-09 | — | — | US | disclosed |
| WO-1990009374-A1 | CYCLOALKYL-SUBSTITUTED GLUTARAMIDE DIURETIC AGENTS | PFIZER LIMITED (GB) | 1990-08-23 | — | — | WO | disclosed |