SCHEMBL9470533

SCHEMBL9470533

CCCCOc1ccc(C#Cc2ccc(F)c(F)c2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 1/20 0.44
ACACB O00763 1/20 0.44
LTA4H P09960 4/20 0.43
HTT P42858 1/20 0.43
RECQL P46063 1/20 0.43
NR5A1 Q13285 1/20 0.42
CHRNB2 P17787 1/20 0.42
CHRNB4 P30926 1/20 0.42
CHRNA3 P32297 1/20 0.42
CHRNA7 P36544 1/20 0.42
CHRNA4 P43681 1/20 0.42
CYP3A4 P08684 1/20 0.41
CYP2D6 P10635 1/20 0.41
RARA P10276 1/20 0.41
RARB P10826 1/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
HSD17B10 Q99714 1/20 0.41
APP P05067 3/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9469637 0.97 NR5A1 (0.47) GRM5ACACBLTA4HHTTRECQL
SCHEMBL9469758 0.95 NR5A1 (0.50) LTA4HHTTNR5A1RARBNPC1
SCHEMBL9470304 0.95 NR5A1 (0.50) LTA4HHTTNR5A1RARBNPC1
SCHEMBL9469736 0.95 NR5A1 (0.50) LTA4HHTTNR5A1RARBNPC1
SCHEMBL9470078 0.95 NR5A1 (0.50) LTA4HHTTNR5A1RARBNPC1
SCHEMBL9469740 0.93 ACACB (0.46) GRM5ACACBLTA4HCHRNB2CHRNB4
SCHEMBL9469465 0.87 LTA4H (0.46) ACACBLTA4HHTTRECQLNR5A1
SCHEMBL9469188 0.86 NQO1 (0.50) GRM5ACACBTSHR
SCHEMBL8767188 0.86 RARB (0.45) HTTCYP3A4CYP2D6RARARARB
SCHEMBL18747506 0.86 ACACB (0.41) ACACBLTA4HHTTRECQLNR5A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5242618-A Liquid crystals MERCK PATENT GESELLSCHAFT (DE) 1993-09-07 US disclosed