SCHEMBL9469740

SCHEMBL9469740

CCCOc1ccc(C#Cc2ccc(F)c(F)c2)cc1

nearest known ligand 0.49

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ACACB O00763 13/20 0.46
GRM5 P41594 1/20 0.44
LTA4H P09960 1/20 0.42
CHRNB2 P17787 1/20 0.42
CHRNB4 P30926 1/20 0.42
CHRNA3 P32297 1/20 0.42
CHRNA7 P36544 1/20 0.42
CHRNA4 P43681 1/20 0.42
APP P05067 3/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9470533 0.93 GRM5 (0.44) ACACBGRM5LTA4HCHRNB2CHRNB4
SCHEMBL9469637 0.90 NR5A1 (0.47) ACACBGRM5LTA4H
SCHEMBL9470078 0.89 NR5A1 (0.50) LTA4H
SCHEMBL9469736 0.89 NR5A1 (0.50) LTA4H
SCHEMBL9469758 0.89 NR5A1 (0.50) LTA4H
SCHEMBL9470304 0.89 NR5A1 (0.50) LTA4H
SCHEMBL8766249 0.87 RARA (0.41) ACACBGRM5APP
SCHEMBL9470588 0.87 LTA4H (0.46) ACACBLTA4HCHRNB2CHRNB4CHRNA3
SCHEMBL9469188 0.86 NQO1 (0.50) ACACBGRM5
SCHEMBL7858945 0.86 FFAR1 (0.47) ACACBCHRNB2CHRNB4CHRNA3CHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5242618-A Liquid crystals MERCK PATENT GESELLSCHAFT (DE) 1993-09-07 US disclosed