Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.49 |
| ▸ | HTR1A | P08908 | 7/20 | 0.49 |
| ▸ | HTR2A | P28223 | 6/20 | 0.49 |
| ▸ | HTR7 | P34969 | 6/20 | 0.49 |
| ▸ | HTR6 | P50406 | 6/20 | 0.49 |
| ▸ | DRD4 | P21917 | 3/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | DRD5 | P21918 | 2/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9470558 | 0.92 | HTR1A (0.39) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL9471849 | 0.88 | DRD2 (0.49) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL9130462 | 0.87 | DRD2 (0.50) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL9130339 | 0.83 | HTR1A (0.57) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL9132214 | 0.82 | DRD2 (0.50) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL9471779 | 0.81 | DRD2 (0.48) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL9471205 | 0.80 | HTR1A (0.51) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL9130468 | 0.79 | HTR1A (0.40) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL9130014 | 0.78 | DRD2 (0.59) | DRD2HTR1AHTR2AHTR7HTR6 | |
| SCHEMBL9134856 | 0.77 | DRD2 (0.60) | DRD2HTR1AHTR2AHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5274097-A | A 1-N-heterocyclic alkylene-3-carbo or heterocyclic ring oxypyrrolidine derivative | BAYER AKTIENGESELLSCHAFT (DE) | 1993-12-28 | — | — | US | disclosed |