Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.31 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ACLY | P53396 | 1/20 | 0.30 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL3862968 | 0.82 | ALDH1A1 (0.56) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL28294050 | 0.80 | ALDH1A1 (0.62) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL27847728 | 0.77 | ALDH1A1 (0.65) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL4728791 | 0.77 | ALDH1A1 (0.71) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL4728788 | 0.77 | ALDH1A1 (0.71) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL7784258 | 0.77 | ALDH1A1 (0.71) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL5606548 | 0.77 | ALDH1A1 (0.71) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL1900557 | 0.77 | ALDH1A1 (0.71) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL6363387 | 0.77 | ALDH1A1 (0.71) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL5049508 | 0.77 | ALDH1A1 (0.71) | ALDH1A1KDM4ELMNAMAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5194182-A | Salt-containing polymer compositions | UNION OIL COMPANY OF CALIFORNIA (US) | 1993-03-16 | — | — | US | disclosed |
| US-5173214-A | Nonaqueous solvent, salt, nonionic surfactant stabilizer | UNION OIL COMPANY OF CALIFORNIA (US) | 1992-12-22 | — | — | US | disclosed |
| US-5145602-A | Antistatic carpet coatings | UNION OIL COMPANY OF CALIFORNIA (US) | 1992-09-08 | — | — | US | disclosed |
| US-5135780-A | Electroless deposition from polymer latex containing metal salts by contacting with reducing agent | UNION OIL COMPANY OF CALIFORNIA (US) | 1992-08-04 | — | — | US | disclosed |
| US-5004562-A | Salt, nonaqueous solvent, stabilizer; electrically conductive | UNION OIL COMPANY OF CALIFORNIA (US) | 1991-04-02 | — | — | US | disclosed |
| WO-1990008798-A1 | LATEX/SOL OR GEL SYSTEMS | UNION OIL COMPANY OF CALIFORNIA (US) | 1990-08-09 | — | — | WO | disclosed |