Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9473390 | 0.90 | ALDH1A1 (0.43) | TP53EGLN3LMNAHPGDALDH1A1 | |
| SCHEMBL9473192 | 0.86 | CCR2 (0.45) | TP53ALDH1A1HSD17B10 | |
| SCHEMBL9474710 | 0.84 | TP53 (0.40) | TP53 | |
| SCHEMBL9473280 | 0.81 | ALDH1A1 (0.45) | TP53ALDH1A1 | |
| SCHEMBL9473284 | 0.81 | ALDH1A1 (0.45) | TP53ALDH1A1 | |
| SCHEMBL9473162 | 0.81 | MEN1 (0.42) | — | |
| SCHEMBL9474084 | 0.81 | MEN1 (0.42) | — | |
| SCHEMBL9483748 | 0.81 | TP53 (0.39) | TP53LMNAHPGDPOLB | |
| SCHEMBL9483752 | 0.81 | TP53 (0.39) | TP53LMNAHPGDPOLB | |
| SCHEMBL7054174 | 0.80 | TP53 (0.48) | TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0437103-A2 | Substituted 5-(alkyl)carboxamide imidazoles | SMITHKLINE BEECHAM CORPORATION (US) | 1991-07-17 | — | — | EP | claimed |
| US-5234917-A | Hypotensive agent, treatment of renal failure or glaucoma | SMITHKLINE BEECHAM CORPORATION | 1993-08-10 | — | — | US | disclosed |
| EP-0437103-A2 | Substituted 5-(alkyl)carboxamide imidazoles | SMITHKLINE BEECHAM CORPORATION (US) | 1991-07-17 | — | — | EP | disclosed |