Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.34 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.34 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9473199 | 0.93 | ALDH1A1 (0.36) | TP53ALDH1A1HSD17B10GAAMEN1 | |
| SCHEMBL9473162 | 0.88 | MEN1 (0.42) | ITGA4ITGB7MEN1KMT2AGPR132 | |
| SCHEMBL9474084 | 0.88 | MEN1 (0.42) | ITGA4ITGB7MEN1KMT2AGPR132 | |
| SCHEMBL9473551 | 0.86 | ITGB2 (0.49) | ALDH1A1 | |
| SCHEMBL9856770 | 0.85 | ITGA4 (0.44) | TP53ITGA4ITGB7ITGB1 | |
| SCHEMBL9474710 | 0.82 | TP53 (0.40) | TP53 | |
| SCHEMBL9473565 | 0.82 | SCN3A (0.41) | ITGA4ITGB7MEN1KMT2AGPR132 | |
| SCHEMBL9857334 | 0.81 | SCN3A (0.41) | ITGA4MEN1KMT2AITGB1 | |
| SCHEMBL9857009 | 0.81 | SCN3A (0.41) | ITGA4MEN1KMT2AITGB1 | |
| SCHEMBL8957085 | 0.79 | TP53 (0.43) | TP53GPR132 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5234917-A | Hypotensive agent, treatment of renal failure or glaucoma | SMITHKLINE BEECHAM CORPORATION | 1993-08-10 | — | — | US | disclosed |
| EP-0437103-A2 | Substituted 5-(alkyl)carboxamide imidazoles | SMITHKLINE BEECHAM CORPORATION (US) | 1991-07-17 | — | — | EP | disclosed |