Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | MYLK | Q15746 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9475728 | 0.91 | ABL1 (0.41) | PTGDR2FFAR1EPHX1TSHRMAPT | |
| SCHEMBL9476368 | 0.91 | TP53 (0.40) | PTGDR2FFAR1EPHX1TSHRMAPT | |
| SCHEMBL9476315 | 0.90 | MAPT (0.41) | PTGDR2FFAR1EPHX1TSHRMAPT | |
| SCHEMBL9476024 | 0.88 | ALDH1A1 (0.41) | PTGDR2FFAR1EPHX1GAAALDH1A1 | |
| SCHEMBL9476282 | 0.87 | SMN1; SMN2 (0.41) | PTGDR2MAPTGAAALDH1A1LMNA | |
| SCHEMBL9476099 | 0.87 | POLB (0.40) | PTGDR2FFAR1MAPTGAANPC1 | |
| SCHEMBL9476156 | 0.87 | FFAR1 (0.38) | PTGDR2FFAR1EPHX1TSHRMAPT | |
| SCHEMBL9476961 | 0.86 | FFAR1 (0.44) | PTGDR2FFAR1EPHX1TSHRMAPT | |
| SCHEMBL9476027 | 0.85 | TP53 (0.40) | PTGDR2FFAR1TSHRMAPTGAA | |
| SCHEMBL9475423 | 0.84 | ALDH1A1 (0.39) | PTGDR2FFAR1TSHRMAPTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5202330-A | Hypotensive and cardiovascular agent, reduces blood pressure in mammals | E. R. SQUIBB & SONS, INC. (US) | 1993-04-13 | — | — | US | disclosed |
| EP-0204317-A2 | 2-Thio or oxo-4-aryl or heterocyclo-1,5(2H)-pyrimidinedicarboxylic acid diesters and 3-acyl-5-pyrimidinecarboxylic acids and esters | E.R. Squibb & Sons, Inc. (US) | 1986-12-10 | — | — | EP | disclosed |