Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 3/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.30 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.30 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9476028 | 0.81 | KDM4C (0.47) | KDM4E | |
| SCHEMBL27362326 | 0.81 | SYK (0.41) | SMN1; SMN2KDM4EALDH1A1HPGDRAB9A | |
| SCHEMBL9475576 | 0.80 | GRM5 (0.42) | SMN1; SMN2KDM4EHTTALDH1A1MAPT | |
| SCHEMBL9476629 | 0.80 | CHEK2 (0.42) | BACE1HSD17B10KDM4EHTTALDH1A1 | |
| SCHEMBL27344045 | 0.75 | TP53 (0.33) | BACE1KDM4EHTTTP53MAPT | |
| SCHEMBL9476499 | 0.71 | ADRA1A (0.47) | BACE1HSD17B10SMN1; SMN2KDM4EHTT | |
| SCHEMBL9476040 | 0.71 | CBFB (0.40) | BACE1HSD17B10SMN1; SMN2KDM4EHTT | |
| SCHEMBL9475451 | 0.71 | CBFB (0.40) | SMN1; SMN2KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL9476263 | 0.71 | KDM4E (0.34) | BACE1HSD17B10SMN1; SMN2KDM4EHTT | |
| SCHEMBL9475729 | 0.70 | KDM4E (0.39) | HSD17B10SMN1; SMN2KDM4EHTTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5270308-A | Hypotensives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-12-14 | — | — | US | disclosed |
| EP-0477789-A1 | 1,3-Benzoxazine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1992-04-01 | — | — | EP | disclosed |