Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | CACNA1F | O60840 | 5/20 | 0.45 |
| ▸ | CACNA1D | Q01668 | 5/20 | 0.45 |
| ▸ | CACNA1S | Q13698 | 5/20 | 0.45 |
| ▸ | CACNA1C | Q13936 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9475421 | 0.85 | ALDH1A1 (0.48) | POLBSMN1; SMN2CACNA1FCACNA1DCACNA1S | |
| SCHEMBL9475783 | 0.80 | LMNA (0.55) | POLBCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL9475842 | 0.80 | CACNA1F (0.47) | POLBCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL9474962 | 0.78 | CACNA1F (0.63) | POLBSMN1; SMN2CACNA1FCACNA1DCACNA1S | |
| SCHEMBL10961726 | 0.78 | POLB (0.54) | POLBSMN1; SMN2KMT2AMEN1TP53 | |
| SCHEMBL9475672 | 0.76 | CACNA1F (0.44) | CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1 | |
| SCHEMBL9474870 | 0.75 | CACNA1C (0.65) | CACNA1FCACNA1DCACNA1SCACNA1CKMT2A | |
| SCHEMBL7384493 | 0.75 | CACNA1C (0.65) | CACNA1FCACNA1DCACNA1SCACNA1CKMT2A | |
| SCHEMBL9475571 | 0.75 | CACNA1F (0.65) | CACNA1FCACNA1DCACNA1SCACNA1CKMT2A | |
| SCHEMBL9652537 | 0.75 | POLB (0.51) | POLBSMN1; SMN2KMT2AMEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5202330-A | Hypotensive and cardiovascular agent, reduces blood pressure in mammals | E. R. SQUIBB & SONS, INC. (US) | 1993-04-13 | — | — | US | disclosed |
| EP-0204317-A2 | 2-Thio or oxo-4-aryl or heterocyclo-1,5(2H)-pyrimidinedicarboxylic acid diesters and 3-acyl-5-pyrimidinecarboxylic acids and esters | E.R. Squibb & Sons, Inc. (US) | 1986-12-10 | — | — | EP | disclosed |