SCHEMBL9475353

SCHEMBL9475353

O=C(c1ccc(Cl)cc1)c1ccc2ccc(C(=O)c3ccc(Cl)cc3)cc2c1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SRD5A2 P31213 3/20 0.59
MAPK1 P28482 1/20 0.59
HPGD P15428 2/20 0.52
CNR2 P34972 2/20 0.50
CES2 O00748 1/20 0.50
CES1 P23141 1/20 0.50
CNR1 P21554 1/20 0.50
HSD17B14 Q9BPX1 1/20 0.49
KMT2A Q03164 3/20 0.48
MEN1 O00255 2/20 0.48
NPC1 O15118 2/20 0.48
RAB9A P51151 2/20 0.48
ALOX15 P16050 1/20 0.48
TSHR P16473 1/20 0.48
HTT P42858 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
CA1 P00915 2/20 0.46
CA2 P00918 2/20 0.46
TDP1 Q9NUW8 1/20 0.46
NR4A1 P22736 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5518679 0.93 SRD5A2 (0.61) SRD5A2MAPK1HPGDCNR2CES2
SCHEMBL9625609 0.90 HSD17B14 (0.62) SRD5A2MAPK1HPGDCNR2CES2
SCHEMBL8967726 0.89 SRD5A2 (0.57) SRD5A2MAPK1HPGDCNR2CES2
SCHEMBL9065412 0.83 SRD5A2 (0.80) SRD5A2MAPK1HPGDCNR2CES2
SCHEMBL1681512 0.83 SRD5A2 (0.80) SRD5A2MAPK1HPGDCNR2CES2
SCHEMBL10697158 0.83 SRD5A2 (0.80) SRD5A2MAPK1HPGDCNR2CES2
SCHEMBL51827 0.83 SRD5A2 (0.80) SRD5A2MAPK1HPGDCNR2CES2
SCHEMBL12274592 0.81 SRD5A2 (0.70) SRD5A2MAPK1HPGDCNR2CES2
SCHEMBL822643 0.81 HPGD (0.56) SRD5A2MAPK1HPGDKMT2AMEN1
Hydrochloric Acid SCHEMBL11704986 0.81 SRD5A2 (0.76) SRD5A2MAPK1HPGDCNR2CES2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5191056-A Molding materials TEIJIN LIMITED (JP) 1993-03-02 US disclosed
US-5126427-A For stable solutions in halogenated hydrocarbons, solvent resistance, thermal poroperties, molding materials, coatings CIBA-GEIGY CORPORATION (US) 1992-06-30 US disclosed
EP-0451104-A2 Soluble polyarylenetherketones CIBA-GEIGY AG (CH) 1991-10-09 EP disclosed
EP-0447358-A2 Soluble polyarylene ether sulfones CIBA-GEIGY AG (CH) 1991-09-18 EP disclosed