Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 11/20 | 0.61 |
| ▸ | ADORA2A | P29274 | 11/20 | 0.61 |
| ▸ | ADORA2B | P29275 | 11/20 | 0.61 |
| ▸ | ADORA1 | P30542 | 11/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9476117 | 0.87 | ALDH1A1 (0.74) | ALDH1A1MAPK1LMNASMN1; SMN2 | |
| SCHEMBL9476250 | 0.84 | ALDH1A1 (0.55) | ALDH1A1MAPK1LMNASMN1; SMN2 | |
| SCHEMBL4046227 | 0.81 | ADORA3 (0.64) | ADORA3ADORA2AADORA2BADORA1ALDH1A1 | |
| SCHEMBL9476091 | 0.81 | ADORA3 (0.62) | ADORA3ADORA2AADORA2BADORA1ALDH1A1 | |
| SCHEMBL9476396 | 0.81 | ALDH1A1 (0.67) | ALDH1A1MAPK1LMNA | |
| SCHEMBL9475939 | 0.79 | ADORA3 (0.60) | ADORA3ADORA2AADORA2BADORA1ALDH1A1 | |
| SCHEMBL9739023 | 0.79 | PDE4A (0.72) | ADORA2AADORA1 | |
| SCHEMBL9477122 | 0.77 | ALDH1A1 (0.64) | ADORA3ADORA2AADORA2BADORA1ALDH1A1 | |
| SCHEMBL4046208 | 0.77 | ADORA3 (0.73) | ADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL4048848 | 0.76 | ADORA3 (1.00) | ADORA3ADORA2AADORA2BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0288431-B1 | 3H-1,2,3-triazolo[4,5-d]pyrimidines | CIBA-GEIGY AG (CH) | 1992-08-19 | — | — | EP | claimed |
| EP-0288431-A1 | 3H-1,2,3-triazolo[4,5-d]pyrimidines | CIBA-GEIGY AG (CH) | 1988-10-26 | — | — | EP | claimed |
| US-5204353-A | 3-benzyl-3H-1,2,3-triazolo[4,5-d]pyrimidines, compositions thereof, and method of treating epilepsy therewith | CIBA-GEIGY CORPORATION (US) | 1993-04-20 | — | — | US | disclosed |
| EP-0288431-B1 | 3H-1,2,3-triazolo[4,5-d]pyrimidines | CIBA-GEIGY AG (CH) | 1992-08-19 | — | — | EP | disclosed |
| EP-0288431-A1 | 3H-1,2,3-triazolo[4,5-d]pyrimidines | CIBA-GEIGY AG (CH) | 1988-10-26 | — | — | EP | disclosed |