Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.67 |
| ▸ | PKM | P14618 | 3/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | PDE4A | P27815 | 3/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.65 |
| ▸ | PDE5A | O76074 | 2/20 | 0.65 |
| ▸ | PDE1A | P54750 | 2/20 | 0.65 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.65 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.65 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.65 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9475021 | 0.86 | ALDH1A1 (0.58) | ALDH1A1PKMPOLBPDE4APDE4B | |
| SCHEMBL9476085 | 0.86 | ALDH1A1 (0.56) | ALDH1A1PKMLMNAMAPK1TSHR | |
| SCHEMBL9476378 | 0.85 | ALDH1A1 (0.74) | ALDH1A1PKMLMNAMAPK1TSHR | |
| SCHEMBL9476453 | 0.85 | ALDH1A1 (0.61) | ALDH1A1PKMPOLBLMNAMAPK1 | |
| SCHEMBL9477074 | 0.84 | ALDH1A1 (0.52) | ALDH1A1PKMPOLBLMNAMAPK1 | |
| SCHEMBL9476430 | 0.82 | ALDH1A1 (0.52) | ALDH1A1PKMLMNAMAPK1TSHR | |
| SCHEMBL9476117 | 0.81 | ALDH1A1 (0.74) | ALDH1A1POLBPDE4APDE4BPDE4C | |
| SCHEMBL9475598 | 0.81 | ALDH1A1 (0.61) | ALDH1A1PKMPOLBLMNATSHR | |
| SCHEMBL9475889 | 0.81 | ALDH1A1 (0.61) | ALDH1A1PKMPOLBLMNAMAPK1 | |
| SCHEMBL9475437 | 0.81 | ADORA3 (0.61) | ALDH1A1LMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0288431-B1 | 3H-1,2,3-triazolo[4,5-d]pyrimidines | CIBA-GEIGY AG (CH) | 1992-08-19 | — | — | EP | claimed |
| EP-0288431-A1 | 3H-1,2,3-triazolo[4,5-d]pyrimidines | CIBA-GEIGY AG (CH) | 1988-10-26 | — | — | EP | claimed |
| US-5204353-A | 3-benzyl-3H-1,2,3-triazolo[4,5-d]pyrimidines, compositions thereof, and method of treating epilepsy therewith | CIBA-GEIGY CORPORATION (US) | 1993-04-20 | — | — | US | disclosed |
| EP-0288431-B1 | 3H-1,2,3-triazolo[4,5-d]pyrimidines | CIBA-GEIGY AG (CH) | 1992-08-19 | — | — | EP | disclosed |
| EP-0288431-A1 | 3H-1,2,3-triazolo[4,5-d]pyrimidines | CIBA-GEIGY AG (CH) | 1988-10-26 | — | — | EP | disclosed |