Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9475439 | 0.85 | MAPT (0.41) | MAPTCES1HDAC1LMNAMAPK1 | |
| SCHEMBL9475911 | 0.82 | MAPT (0.50) | MAPTCES1LMNAMAPK1ALDH1A1 | |
| SCHEMBL9476200 | 0.82 | CES1 (0.42) | MAPTCES1LMNAMAPK1ALDH1A1 | |
| SCHEMBL9475925 | 0.82 | MAPT (0.43) | MAPTCES1LMNAMAPK1ALDH1A1 | |
| SCHEMBL9475312 | 0.82 | LMNA (0.45) | MAPTHDAC1LMNAMAPK1ALDH1A1 | |
| SCHEMBL5580542 | 0.82 | CES1 (0.69) | MAPTCES1HDAC1MAPK1ALDH1A1 | |
| SCHEMBL6188679 | 0.79 | CES1 (0.56) | MAPTCES1LMNAKCNN4NPC1 | |
| SCHEMBL5877921 | 0.79 | MAPT (0.50) | MAPTHDAC1LMNAMAPK1ALDH1A1 | |
| SCHEMBL9475849 | 0.77 | CES1 (0.53) | CES1LMNAALDH1A1KCNN4NPC1 | |
| SCHEMBL9475726 | 0.77 | PLK1 (0.51) | MAPTLMNAMAPK1ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5243066-A | ALKYL 2-ARYL-2,2-DIALKOXYACETATES, THE PREPARATION THEREOF AND A METHOD OF USING THEM FOR PREPARING ARYLGLYOXYLIC ESTERS | BASF AKTIENGESELLSCHAFT (DE) | 1993-09-07 | — | — | US | disclosed |