Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL9475677 | 1.00 | KMT2A (0.40) | KMT2AMEN1ALDH1A1MAPTKDM4E | |
| Bromide SCHEMBL9475355 | 0.88 | ACHE (0.42) | MAPTKDM4ECASP1MAPK1GAA | |
| Bromide SCHEMBL9475350 | 0.88 | ACHE (0.42) | MAPTKDM4ECASP1MAPK1GAA | |
| Bromide SCHEMBL9476998 | 0.77 | PDPK1 (0.38) | ALDH1A1MAPTGRM5GAA | |
| SCHEMBL11738428 | 0.76 | KMT2A (0.43) | KMT2AMEN1ALDH1A1MAPTKDM4E | |
| SCHEMBL11510279 | 0.75 | KMT2A (0.43) | KMT2AMEN1ALDH1A1MAPTKDM4E | |
| Bromide SCHEMBL7430276 | 0.74 | ACHE (0.36) | KMT2AALDH1A1KDM4ECASP1HTR2A | |
| Bromide SCHEMBL7433533 | 0.72 | PDE4A (0.33) | — | |
| SCHEMBL9476703 | 0.71 | KMT2A (0.33) | KMT2AMEN1KDM4EHSD17B10HTR2C | |
| SCHEMBL9478024 | 0.71 | KMT2A (0.33) | KMT2AMEN1HPGDHSD17B10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5218117-A | Antiallergens, antiinflammatory agents | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) | 1993-06-08 | — | — | US | disclosed |
| US-5179089-A | Antiallergens, asthma | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) | 1993-01-12 | — | — | US | disclosed |
| EP-0486211-A1 | Isoquinoline derivatives | CHINOIN Gyògyszer és Vegyészeti Termékek Gyára RT. (HU) | 1992-05-20 | — | — | EP | disclosed |