Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 7/20 | 0.37 |
| ▸ | ABCC9 | O60706 | 4/20 | 0.37 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.37 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.37 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9846798 | 0.74 | PDE4A (0.39) | ABCB1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL9372531 | 0.70 | ABCC9 (0.47) | ABCB1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL9375925 | 0.69 | ABCC9 (0.44) | ABCB1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL9372439 | 0.69 | ABCC9 (0.39) | ABCB1ABCC9BACE1KDM4EMALT1 | |
| SCHEMBL9375996 | 0.69 | ABCB1 (0.36) | ABCB1ABCC9CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL9372094 | 0.67 | ABCC9 (0.36) | ABCB1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL9371935 | 0.67 | ABCC9 (0.38) | ABCB1ABCC9BACE1MAP3K5MALT1 | |
| SCHEMBL9377494 | 0.66 | ABCC9 (0.38) | ABCB1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL9373199 | 0.66 | ABCC9 (0.36) | ABCB1ABCC9BACE1MALT1PDE4A | |
| SCHEMBL9375563 | 0.66 | ABCC9 (0.35) | ABCB1ABCC9ABCC8KCNJ11KCNJ8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0477789-A1 | 1,3-Benzoxazine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1992-04-01 | — | — | EP | claimed |
| US-5270308-A | Hypotensives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-12-14 | — | — | US | disclosed |
| EP-0477789-A1 | 1,3-Benzoxazine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1992-04-01 | — | — | EP | disclosed |