Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | ABCC9 | O60706 | 4/20 | 0.37 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.37 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.37 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.36 |
| ▸ | BACE1 | P56817 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9846720 | 0.84 | PBRM1 (0.37) | LMNABACE1HTR2AMALT1CTSD | |
| SCHEMBL9846701 | 0.81 | ATM (0.33) | MAP3K5BACE1CTSD | |
| SCHEMBL9372531 | 0.81 | ABCC9 (0.47) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL9375925 | 0.80 | ABCC9 (0.44) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL9372094 | 0.78 | ABCC9 (0.36) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL9475989 | 0.74 | ABCB1 (0.37) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL9779616 | 0.74 | ABCC9 (0.42) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL9475195 | 0.74 | BACE1 (0.33) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL9372975 | 0.73 | ABCC9 (0.35) | PDE4APDE4BPDE4CPDE4DABCC9 | |
| SCHEMBL9374699 | 0.73 | ABCC9 (0.37) | PDE4APDE4BPDE4CPDE4DABCC9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0450487-A1 | Benzoxazine derivatives, method for their preparation and their use for treating or prophylaxis of diseases | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-09 | — | — | EP | disclosed |