Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.34 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9475490 | 0.71 | ATM (0.48) | ATMRAB9ANPC1MEN1KMT2A | |
| SCHEMBL9477126 | 0.71 | ATM (0.48) | ATMRAB9AKDM4EMAPTHTT | |
| SCHEMBL645287 | 0.67 | CYP3A4 (0.42) | ATMCYP3A4RAB9AMAPTNPC1 | |
| SCHEMBL11095195 | 0.67 | TSHR (0.46) | ATMCYP3A4RAB9AKDM4EMAPT | |
| SCHEMBL9476641 | 0.67 | ATM (0.44) | ATMRAB9AKDM4EMAPTHTT | |
| SCHEMBL2315874 | 0.64 | ATM (0.50) | ATMCYP3A4RAB9AKDM4EMAPT | |
| SCHEMBL19329417 | 0.64 | ATM (0.50) | ATMCYP3A4RAB9AKDM4EMAPT | |
| SCHEMBL5777213 | 0.64 | MAPT (0.54) | ATMCYP3A4RAB9AKDM4EMAPT | |
| SCHEMBL3384539 | 0.64 | ALDH1A1 (0.50) | ATMCYP3A4RAB9AMAPTHTT | |
| SCHEMBL1128345 | 0.63 | CYP3A4 (0.43) | CYP3A4RAB9AMAPTNPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5270308-A | Hypotensives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-12-14 | — | — | US | claimed |
| US-5270308-A | Hypotensives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-12-14 | — | — | US | disclosed |
| EP-0477789-A1 | 1,3-Benzoxazine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1992-04-01 | — | — | EP | disclosed |