Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.47 |
| ▸ | HTR2C known ✓ | P28335 | 1/20 | 0.47 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 9/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.45 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.41 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.41 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.41 |
| ▸ | EBP | Q15125 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL9477409 | 1.00 | HTR2A (0.47) | HTR2AHTR2CP2RX7ROCK2ROCK1 | |
| Fumaric Acid SCHEMBL9479494 | 0.94 | P2RX7 (0.46) | HTR2AHTR2CP2RX7ROCK2ROCK1 | |
| Fumaric Acid SCHEMBL9478898 | 0.91 | P2RX7 (0.48) | HTR2AHTR2CP2RX7ROCK2ROCK1 | |
| Fumaric Acid SCHEMBL9478905 | 0.91 | P2RX7 (0.48) | HTR2AHTR2CP2RX7ROCK2ROCK1 | |
| Hydrochloric Acid SCHEMBL9477617 | 0.87 | HTR2A (0.48) | HTR2AHTR2CP2RX7ROCK2ROCK1 | |
| SCHEMBL9046051 | 0.87 | HTR2A (0.48) | HTR2AHTR2CP2RX7ROCK2ROCK1 | |
| Hydrochloric Acid SCHEMBL9477677 | 0.85 | HTR2A (0.46) | HTR2AHTR2CP2RX7ROCK2ROCK1 | |
| Hydrochloric Acid SCHEMBL9485119 | 0.83 | HTR2A (0.48) | HTR2AHTR2CROCK2ROCK1HRH3 | |
| SCHEMBL9477706 | 0.80 | P2RX7 (0.49) | HTR2AHTR2CP2RX7ROCK2ROCK1 | |
| Hydrochloric Acid SCHEMBL9479281 | 0.80 | HTR2A (0.46) | HTR2AHTR2CP2RX7ROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5208243-A | Analgesics | ADIR ET COMPAGNIE (FR) | 1993-05-04 | — | — | US | disclosed |