Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 12/20 | 0.94 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.94 |
| ▸ | CETP | P11597 | 1/20 | 0.94 |
| ▸ | IGF1R | P08069 | 2/20 | 0.62 |
| ▸ | SRC | P12931 | 2/20 | 0.62 |
| ▸ | AXL | P30530 | 2/20 | 0.62 |
| ▸ | KDR | P35968 | 2/20 | 0.62 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.62 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.62 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.62 |
| ▸ | MET | P08581 | 1/20 | 0.62 |
| ▸ | PIM1 | P11309 | 1/20 | 0.62 |
| ▸ | AKT1 | P31749 | 1/20 | 0.62 |
| ▸ | NEK2 | P51955 | 1/20 | 0.62 |
| ▸ | PLK1 | P53350 | 1/20 | 0.62 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.62 |
| ▸ | NEK6 | Q9HC98 | 1/20 | 0.62 |
| ▸ | PTPN6 | P29350 | 3/20 | 0.59 |
| ▸ | ACLY | P53396 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Avarol SCHEMBL31517137 | 0.97 | PTPN1 (1.00) | PTPN1PTGS2CETPIGF1RSRC | |
| Avarol SCHEMBL21397196 | 0.97 | PTPN1 (1.00) | PTPN1PTGS2CETPIGF1RSRC | |
| Avarol SCHEMBL186460 | 0.97 | PTPN1 (1.00) | PTPN1PTGS2CETPIGF1RSRC | |
| Avarol SCHEMBL10402772 | 0.97 | PTPN1 (1.00) | PTPN1PTGS2CETPIGF1RSRC | |
| Avarol SCHEMBL9477102 | 0.96 | PTPN1 (0.98) | PTPN1PTGS2CETPIGF1RSRC | |
| Avarol SCHEMBL9478364 | 0.90 | PTPN1 (0.80) | PTPN1PTGS2CETPIGF1RSRC | |
| Avarone SCHEMBL5806251 | 0.85 | PTPN1 (0.77) | PTPN1PTGS2CETPIGF1RSRC | |
| SCHEMBL31536047 | 0.83 | PTPN1 (1.00) | PTPN1PTGS2CETPIGF1RSRC | |
| SCHEMBL9478317 | 0.79 | PTPN1 (0.78) | PTPN1PTGS2CETPIGF1RSRC | |
| SCHEMBL31536088 | 0.78 | PTPN1 (0.68) | PTPN1PTGS2CETPIGF1RSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5180748-A | Antitumor agents | MERZ+CO. GMBH & CO. (DE) | 1993-01-19 | — | — | US | disclosed |
| US-5082865-A | Avarol and its production and use as an antitumor agent (I) | MUELLER WERNER E G (DE) | 1992-01-21 | — | — | US | disclosed |
| US-4946869-A | IN THE FORMS OF TABLETS, CAPSULES, ELIXIRS, SUPPOSITORIES OR STERILE INJECTABLE SOLUTIONS | MERZ AND CO. GMBH & CO. (DE) | 1990-08-07 | — | — | US | disclosed |