Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 20/20 | 0.61 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL948546 | 0.79 | S1PR1 (0.55) | S1PR1S1PR4S1PR5 | |
| SCHEMBL950551 | 0.72 | S1PR1 (1.00) | S1PR1S1PR4S1PR5 | |
| SCHEMBL12944511 | 0.71 | S1PR1 (0.79) | S1PR1S1PR4S1PR5 | |
| SCHEMBL10011429 | 0.65 | PPARD (0.62) | — | |
| SCHEMBL4056753 | 0.64 | CA1 (0.51) | — | |
| SCHEMBL3947555 | 0.62 | PPARD (0.65) | — | |
| SCHEMBL598333 | 0.61 | CA1 (0.50) | — | |
| SCHEMBL13933202 | 0.61 | CA1 (0.49) | — | |
| SCHEMBL3675353 | 0.61 | KDM4E (0.42) | — | |
| SCHEMBL7796039 | 0.61 | ITGB3 (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011005295-A1 | MODULATORS OF THE SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | disclosed |