Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 7/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | KCNA1 | Q09470 | 2/20 | 0.38 |
| ▸ | KCNAB1 | Q14722 | 2/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | IDH2 | P48735 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9478847 | 0.92 | MEN1 (0.47) | MEN1KMT2AEPHX2TP53NAMPT | |
| SCHEMBL9478180 | 0.90 | CA2 (0.44) | MEN1KMT2ATP53NAMPTCA1 | |
| SCHEMBL9476568 | 0.90 | CA1 (0.40) | MEN1KMT2ATP53CA1CA2 | |
| SCHEMBL9478799 | 0.89 | MEN1 (0.60) | MEN1KMT2ATP53CA1CA2 | |
| SCHEMBL9478804 | 0.86 | MEN1 (0.48) | MEN1KMT2ATP53CA1CA2 | |
| SCHEMBL9480079 | 0.86 | MEN1 (0.48) | MEN1KMT2ATP53NAMPTCA1 | |
| SCHEMBL9478543 | 0.86 | HRH3 (0.49) | EPHX2TP53CA1CA2CA9 | |
| SCHEMBL9477511 | 0.85 | TP53 (0.56) | MEN1KMT2ATP53CA1CA2 | |
| SCHEMBL9478434 | 0.84 | MEN1 (0.48) | MEN1KMT2ATP53CA1CA2 | |
| SCHEMBL9564640 | 0.84 | CA2 (0.52) | MEN1KMT2ACA2KCNA1KCNAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5262440-A | Treatment of neoplasms | ELI LILLY AND COMPANY (US) | 1993-11-16 | — | — | US | disclosed |
| EP-0546763-A1 | Antitumor compositions and methods of treatment | ELI LILLY AND COMPANY (US) | 1993-06-16 | — | — | EP | disclosed |