Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 6/20 | 0.39 |
| ▸ | CA9 | Q16790 | 6/20 | 0.39 |
| ▸ | CA2 | P00918 | 6/20 | 0.39 |
| ▸ | CA1 | P00915 | 5/20 | 0.39 |
| ▸ | KCNA1 | Q09470 | 7/20 | 0.39 |
| ▸ | KCNAB1 | Q14722 | 7/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | FBP1 | P09467 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9478434 | 0.92 | MEN1 (0.48) | MEN1KMT2AIDO1TP53CA12 | |
| SCHEMBL9478605 | 0.92 | MEN1 (0.48) | MEN1KMT2AIDO1TP53CA12 | |
| SCHEMBL9478799 | 0.90 | MEN1 (0.60) | MEN1KMT2ATP53CA12CA9 | |
| SCHEMBL9480079 | 0.87 | MEN1 (0.48) | MEN1KMT2AIDO1TP53CA12 | |
| SCHEMBL9478350 | 0.87 | MEN1 (0.45) | MEN1KMT2ACA12CA9CA2 | |
| SCHEMBL9478282 | 0.86 | MEN1 (0.47) | MEN1KMT2ATP53CA9CA2 | |
| SCHEMBL9476500 | 0.85 | CA1 (0.46) | MEN1KMT2AIDO1TP53CA12 | |
| SCHEMBL9477511 | 0.85 | TP53 (0.56) | MEN1KMT2ATP53CA12CA9 | |
| SCHEMBL9564640 | 0.85 | CA2 (0.52) | MEN1KMT2AIDO1CA2KCNA1 | |
| SCHEMBL9478322 | 0.85 | CNR2 (0.43) | MEN1KMT2ACA12CA9CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5262440-A | Treatment of neoplasms | ELI LILLY AND COMPANY (US) | 1993-11-16 | — | — | US | disclosed |
| EP-0546763-A1 | Antitumor compositions and methods of treatment | ELI LILLY AND COMPANY (US) | 1993-06-16 | — | — | EP | disclosed |