Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KCNA1 | Q09470 | 7/20 | 0.44 |
| ▸ | KCNAB1 | Q14722 | 7/20 | 0.44 |
| ▸ | FBP1 | P09467 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FLT4 | P35916 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 4/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9478350 | 0.92 | MEN1 (0.45) | MEN1KMT2AMAPTLMNAHTT | |
| SCHEMBL9480088 | 0.92 | KCNA1 (0.44) | MEN1KMT2AMAPTKCNA1KCNAB1 | |
| SCHEMBL9477595 | 0.90 | EPHX1 (0.47) | MEN1KMT2AMAPTLMNAHTT | |
| SCHEMBL9478605 | 0.87 | MEN1 (0.48) | MEN1KMT2ALMNAALDH1A1KCNA1 | |
| SCHEMBL7983217 | 0.85 | KCNA1 (0.53) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL9478381 | 0.85 | CA1 (0.46) | MEN1KMT2ALMNAKCNA1KCNAB1 | |
| SCHEMBL9478165 | 0.85 | MEN1 (0.48) | MEN1KMT2ALMNAALDH1A1KCNA1 | |
| SCHEMBL9480112 | 0.85 | MEN1 (0.48) | MEN1KMT2AMAPTKCNA1KCNAB1 | |
| SCHEMBL9478768 | 0.85 | CA2 (0.44) | MEN1KMT2AMAPTKCNA1KCNAB1 | |
| SCHEMBL9478322 | 0.83 | CNR2 (0.43) | MEN1KMT2AMAPTKCNA1KCNAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5262440-A | Treatment of neoplasms | ELI LILLY AND COMPANY (US) | 1993-11-16 | — | — | US | disclosed |
| EP-0546763-A1 | Antitumor compositions and methods of treatment | ELI LILLY AND COMPANY (US) | 1993-06-16 | — | — | EP | disclosed |