Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA1 | Q09470 | 3/20 | 0.53 |
| ▸ | KCNAB1 | Q14722 | 3/20 | 0.53 |
| ▸ | FBP1 | P09467 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 7/20 | 0.46 |
| ▸ | CA1 | P00915 | 7/20 | 0.46 |
| ▸ | CA2 | P00918 | 7/20 | 0.46 |
| ▸ | CA9 | Q16790 | 7/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA5A | P35218 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7983130 | 0.91 | KCNA1 (0.50) | KCNA1KCNAB1FBP1CA12CA1 | |
| SCHEMBL9477595 | 0.88 | EPHX1 (0.47) | KCNA1KCNAB1FBP1CA12CA1 | |
| SCHEMBL9478381 | 0.88 | CA1 (0.46) | KCNA1KCNAB1FBP1CA12CA1 | |
| SCHEMBL9478237 | 0.88 | TP53 (0.56) | KCNA1KCNAB1FBP1CA12CA1 | |
| SCHEMBL9477487 | 0.86 | MEN1 (0.60) | KCNA1KCNAB1FBP1CA12CA2 | |
| SCHEMBL9480088 | 0.85 | KCNA1 (0.44) | KCNA1KCNAB1FBP1CA12CA1 | |
| SCHEMBL9480112 | 0.85 | MEN1 (0.48) | KCNA1KCNAB1FBP1CA12CA1 | |
| SCHEMBL9478331 | 0.85 | MEN1 (0.45) | KCNA1KCNAB1FBP1CA12CA1 | |
| SCHEMBL9478784 | 0.85 | CA12 (0.49) | KCNA1KCNAB1CA12CA1CA2 | |
| SCHEMBL9478165 | 0.83 | MEN1 (0.48) | KCNA1KCNAB1FBP1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5262440-A | Treatment of neoplasms | ELI LILLY AND COMPANY (US) | 1993-11-16 | — | — | US | claimed |
| EP-0546763-A1 | Antitumor compositions and methods of treatment | ELI LILLY AND COMPANY (US) | 1993-06-16 | — | — | EP | claimed |
| JP-5294923-A | — | — | None | — | — | JP | disclosed |
| US-6281240-B1 | CYSTIC FIBROSIS | ELI LILLY AND COMPANY | 2001-08-28 | — | — | US | disclosed |
| WO-1998044799-A1 | DIARYLSULFONYLUREAS FOR USE IN TREATING SECRETORY DIARRHEA | ELI LILLY AND COMPANY (US) | 1998-10-15 | — | — | WO | disclosed |
| EP-0606723-A1 | Imidazolidin-2-one derivatives and their use as antitumor agents | ELI LILLY AND COMPANY (US) | 1994-07-20 | — | — | EP | disclosed |
| US-5270329-A | 1-arylsulfonyl-imidazolidin-2-one derivatives | ELI LILLY AND COMPANY (US) | 1993-12-14 | — | — | US | disclosed |
| US-5262440-A | Treatment of neoplasms | ELI LILLY AND COMPANY (US) | 1993-11-16 | — | — | US | disclosed |
| JP-H05294923-A | ANTITUMOR COMPOSITION AND TREATMENT WITH THE SAME | ELI LILLY & CO | 1993-11-09 | — | — | JP | disclosed |
| EP-0546763-A1 | Antitumor compositions and methods of treatment | ELI LILLY AND COMPANY (US) | 1993-06-16 | — | — | EP | disclosed |