Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.54 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.46 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10369697 | 0.93 | CYSLTR2 (0.52) | CYSLTR2CYSLTR1EPHX2NR1H4RAB9A | |
| SCHEMBL9806734 | 0.87 | CYSLTR1 (0.74) | CYSLTR2CYSLTR1EPHX2GAAKMT2A | |
| SCHEMBL9480363 | 0.82 | CYSLTR2 (0.43) | CYSLTR2CYSLTR1RAB9ANPC1CASP1 | |
| SCHEMBL8998138 | 0.82 | CYSLTR2 (0.77) | CYSLTR2CYSLTR1EPHX2NR1H4PLA2G4A | |
| SCHEMBL9806763 | 0.81 | CYSLTR2 (0.76) | CYSLTR2CYSLTR1EPHX2NR1H4PLA2G4A | |
| SCHEMBL8951226 | 0.81 | EPHX2 (0.47) | EPHX2NR1H4AGTR1AGTR2RAB9A | |
| SCHEMBL9477836 | 0.80 | CYSLTR2 (0.53) | CYSLTR2CYSLTR1EPHX2NR1H4AGTR1 | |
| SCHEMBL9479016 | 0.79 | CYSLTR2 (0.61) | CYSLTR2CYSLTR1EPHX2NR1H4 | |
| SCHEMBL10369905 | 0.77 | PLA2G4A (0.47) | CYSLTR2CYSLTR1EPHX2NR1H4AGTR1 | |
| SCHEMBL9806759 | 0.77 | CYSLTR2 (0.47) | CYSLTR2CYSLTR1EPHX2NR1H4AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5234942-A | Treating allergic pulmonary disorders, asthma | ICI AMERICAS INC. (US) | 1993-08-10 | — | — | US | disclosed |
| US-4997844-A | Compounds for the treatment of allergic or inflammatory diseases or shock conditions | ICI AMERICAS INC. (US) | 1991-03-05 | — | — | US | disclosed |