Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.55 |
| ▸ | PKM | P14618 | 2/20 | 0.55 |
| ▸ | ALPI | P09923 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | XIAP | P98170 | 1/20 | 0.55 |
| ▸ | NOS3 | P29474 | 3/20 | 0.54 |
| ▸ | NOS1 | P29475 | 3/20 | 0.54 |
| ▸ | NOS2 | P35228 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | BLM | P54132 | 2/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.49 |
| ▸ | MPO | P05164 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9479354 | 1.00 | SLC7A5 (0.55) | SLC7A5PKMALPIPTGS1XIAP | |
| SCHEMBL1527682 | 0.86 | PKM (0.58) | SLC7A5PKMALPIPTGS1XIAP | |
| SCHEMBL1527683 | 0.86 | PKM (0.58) | SLC7A5PKMALPIPTGS1XIAP | |
| SCHEMBL29475631 | 0.86 | PKM (0.58) | SLC7A5PKMALPIPTGS1XIAP | |
| SCHEMBL31370153 | 0.86 | PKM (0.58) | SLC7A5PKMALPIPTGS1XIAP | |
| SCHEMBL15921435 | 0.85 | NOS3 (0.56) | SLC7A5PKMALPIPTGS1XIAP | |
| SCHEMBL202930 | 0.85 | NOS3 (0.56) | SLC7A5PKMALPIPTGS1XIAP | |
| SCHEMBL42486 | 0.84 | NOS3 (0.59) | SLC7A5PKMALPIPTGS1XIAP | |
| SCHEMBL29637605 | 0.84 | NOS3 (0.59) | SLC7A5PKMALPIPTGS1XIAP | |
| SCHEMBL30440587 | 0.84 | NOS3 (0.59) | SLC7A5PKMALPIPTGS1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5208228-A | Skin disorders | MERCK & CO., INC. (US) | 1993-05-04 | — | — | US | claimed |
| EP-0428365-A1 | Aminomacrolides and derivatives having immunosuppressive activity | MERCK & CO. INC. (US) | 1991-05-22 | — | — | EP | claimed |
| US-5208228-A | Skin disorders | MERCK & CO., INC. (US) | 1993-05-04 | — | — | US | disclosed |
| EP-0428365-A1 | Aminomacrolides and derivatives having immunosuppressive activity | MERCK & CO. INC. (US) | 1991-05-22 | — | — | EP | disclosed |