Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 11/20 | 0.60 |
| ▸ | CYSLTR1 | Q9Y271 | 11/20 | 0.60 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10368401 | 0.93 | CYSLTR2 (0.69) | CYSLTR2CYSLTR1 | |
| SCHEMBL9479293 | 0.87 | CYSLTR2 (0.56) | CYSLTR2CYSLTR1NAMPT | |
| SCHEMBL9481158 | 0.87 | CYSLTR1 (0.54) | CYSLTR2CYSLTR1 | |
| SCHEMBL27673281 | 0.86 | CYSLTR2 (0.54) | CYSLTR2CYSLTR1NAMPT | |
| SCHEMBL10367474 | 0.86 | CYSLTR1 (0.63) | CYSLTR2CYSLTR1 | |
| SCHEMBL8998286 | 0.84 | EPHX2 (0.56) | CYSLTR2CYSLTR1NAMPTLMNA | |
| SCHEMBL8951100 | 0.82 | CYSLTR2 (0.53) | CYSLTR2CYSLTR1NAMPTLMNA | |
| SCHEMBL8951163 | 0.82 | CYSLTR2 (0.56) | CYSLTR2CYSLTR1NAMPTLMNA | |
| SCHEMBL8901046 | 0.82 | CYSLTR2 (0.64) | CYSLTR2CYSLTR1 | |
| SCHEMBL10369756 | 0.80 | CYSLTR1 (0.63) | CYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5234942-A | Treating allergic pulmonary disorders, asthma | ICI AMERICAS INC. (US) | 1993-08-10 | — | — | US | disclosed |
| US-4997844-A | Compounds for the treatment of allergic or inflammatory diseases or shock conditions | ICI AMERICAS INC. (US) | 1991-03-05 | — | — | US | disclosed |
| EP-0179619-B1 | HETEROCYCLIC AMIDES | ICI AMERICAS INC. (US) | 1990-09-05 | — | — | EP | disclosed |
| EP-0179619-A1 | Heterocyclic amides | ICI AMERICAS INC. (US) | 1986-04-30 | — | — | EP | disclosed |