Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.46 |
| ▸ | CRHBP | P24387 | 2/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.44 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9481094 | 0.82 | LMNA (0.48) | ALDH1A1HDAC1MEN1KMT2ALMNA | |
| SCHEMBL9806749 | 0.81 | HDAC1 (0.41) | ALDH1A1HDAC1CRHBPCRHR2MEN1 | |
| SCHEMBL9479152 | 0.79 | HDAC3 (0.55) | HDAC1LMNASMN1; SMN2KCNQ2HDAC3 | |
| SCHEMBL9481922 | 0.79 | HDAC3 (0.55) | HDAC1LMNASMN1; SMN2KCNQ2HDAC3 | |
| SCHEMBL9479109 | 0.73 | ALDH1A1 (0.51) | ALDH1A1HDAC1CRHBPCRHR2MEN1 | |
| SCHEMBL9493585 | 0.71 | EPHX2 (0.57) | ALDH1A1HDAC1CRHBPCRHR2MEN1 | |
| SCHEMBL9480597 | 0.69 | CDK4 (0.74) | LMNACYP1A2CYP3A4 | |
| SCHEMBL9479598 | 0.68 | HDAC3 (0.59) | HDAC1LMNASMN1; SMN2KCNQ2HDAC3 | |
| SCHEMBL19074542 | 0.68 | ALDH1A1 (0.82) | ALDH1A1HDAC1CRHBPCRHR2MEN1 | |
| SCHEMBL7752354 | 0.68 | ALDH1A1 (0.82) | ALDH1A1HDAC1CRHBPCRHR2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5234942-A | Treating allergic pulmonary disorders, asthma | ICI AMERICAS INC. (US) | 1993-08-10 | — | — | US | disclosed |
| US-4997844-A | Compounds for the treatment of allergic or inflammatory diseases or shock conditions | ICI AMERICAS INC. (US) | 1991-03-05 | — | — | US | disclosed |
| EP-0179619-B1 | HETEROCYCLIC AMIDES | ICI AMERICAS INC. (US) | 1990-09-05 | — | — | EP | disclosed |
| EP-0179619-A1 | Heterocyclic amides | ICI AMERICAS INC. (US) | 1986-04-30 | — | — | EP | disclosed |