Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 1/20 | 0.53 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.53 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.53 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ADA | P00813 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9806765 | 0.85 | KCNQ3 (0.60) | KCNQ3KCNQ2KCNQ4KCNQ5SMN1; SMN2 | |
| SCHEMBL9479618 | 0.78 | EPHX2 (0.58) | KCNQ3KCNQ2KCNQ4KCNQ5SMN1; SMN2 | |
| SCHEMBL9479019 | 0.78 | KDM4E (0.47) | NPC1LMNARAB9AALDH1A1NPSR1 | |
| SCHEMBL9479236 | 0.78 | KCNQ3 (0.60) | KCNQ3KCNQ2KCNQ4KCNQ5SMN1; SMN2 | |
| SCHEMBL9479510 | 0.78 | ALDH1A1 (0.51) | SMN1; SMN2NPC1LMNARAB9AHDAC3 | |
| SCHEMBL9479659 | 0.76 | HDAC3 (0.57) | KCNQ3KCNQ2KCNQ4KCNQ5SMN1; SMN2 | |
| SCHEMBL9478816 | 0.75 | ADA (0.59) | KCNQ3KCNQ2KCNQ4KCNQ5SMN1; SMN2 | |
| SCHEMBL9806732 | 0.74 | ADA (0.58) | KCNQ3KCNQ2KCNQ4KCNQ5SMN1; SMN2 | |
| SCHEMBL9479598 | 0.74 | HDAC3 (0.59) | KCNQ3KCNQ2KCNQ4KCNQ5SMN1; SMN2 | |
| SCHEMBL9481232 | 0.74 | KCNQ3 (0.53) | KCNQ3KCNQ2KCNQ4KCNQ5SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5234942-A | Treating allergic pulmonary disorders, asthma | ICI AMERICAS INC. (US) | 1993-08-10 | — | — | US | disclosed |
| US-4997844-A | Compounds for the treatment of allergic or inflammatory diseases or shock conditions | ICI AMERICAS INC. (US) | 1991-03-05 | — | — | US | disclosed |
| EP-0179619-B1 | HETEROCYCLIC AMIDES | ICI AMERICAS INC. (US) | 1990-09-05 | — | — | EP | disclosed |