Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAB2 | O43741 | 1/20 | 0.39 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.39 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.39 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.39 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.39 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.39 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 3/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.31 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9819549 | 1.00 | PRKAB2 (0.39) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL15758912 | 0.80 | PRKAB2 (0.48) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL10368149 | 0.76 | PARP1 (0.34) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL9482840 | 0.76 | PARP1 (0.34) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL9482846 | 0.76 | PARP1 (0.34) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL10768530 | 0.75 | DPP4 (0.35) | HTR2CHTR2BDRD2DRD3AADAT | |
| SCHEMBL10622022 | 0.75 | DPP4 (0.35) | HTR2CHTR2BDRD2DRD3AADAT | |
| SCHEMBL10510418 | 0.73 | AOC2 (0.42) | — | |
| SCHEMBL10510413 | 0.73 | AOC2 (0.42) | — | |
| SCHEMBL3346784 | 0.72 | PRKAB2 (0.36) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5190967-A | Sexual dysfunction | GLAXO GROUP LIMITED (GB) | 1993-03-02 | — | — | US | disclosed |
| EP-0460912-A2 | Medicaments for the treatment of sexual disorder | GLAXO GROUP LIMITED (GB) | 1991-12-11 | — | — | EP | disclosed |
| EP-0224332-B1 | HETEROCYCLIC AMINO COMPOUNDS | GLAXO GROUP LIMITED (GB) | 1990-08-08 | — | — | EP | disclosed |
| US-4769367-A | ANTIDEPRESSANTS | GLAXO GROUP LIMITED (GB) | 1988-09-06 | — | — | US | disclosed |
| EP-0224332-A1 | Heterocyclic amino compounds | GLAXO GROUP LIMITED (GB) | 1987-06-03 | — | — | EP | disclosed |