Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.34 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.33 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.33 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.33 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.33 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.33 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.32 |
| ▸ | MIF | P14174 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9482846 | 1.00 | PARP1 (0.34) | PARP1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL9482840 | 1.00 | PARP1 (0.34) | PARP1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL10618284 | 0.80 | L3MBTL1 (0.34) | ALDH1A1MAPTITGA4L3MBTL1KDM4E | |
| SCHEMBL10618280 | 0.80 | L3MBTL1 (0.34) | ALDH1A1MAPTITGA4L3MBTL1KDM4E | |
| SCHEMBL9482188 | 0.76 | PRKAB2 (0.39) | PARP1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL9819549 | 0.76 | PRKAB2 (0.39) | PARP1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL15758912 | 0.72 | PRKAB2 (0.48) | PARP1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL15882879 | 0.71 | NFKB1 (0.41) | L3MBTL1 | |
| SCHEMBL10471599 | 0.68 | L3MBTL1 (0.36) | ALDH1A1MAPTL3MBTL1KDM4EHPGD | |
| SCHEMBL3346784 | 0.67 | PRKAB2 (0.36) | PARP1PRKAB2PRKAG1PRKAA2PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0224332-B1 | HETEROCYCLIC AMINO COMPOUNDS | GLAXO GROUP LIMITED (GB) | 1990-08-08 | — | — | EP | disclosed |
| EP-0224332-A1 | Heterocyclic amino compounds | GLAXO GROUP LIMITED (GB) | 1987-06-03 | — | — | EP | disclosed |