Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.63 |
| ▸ | HTT | P42858 | 4/20 | 0.63 |
| ▸ | MEN1 | O00255 | 4/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.63 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.63 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | ATM | Q13315 | 1/20 | 0.63 |
| ▸ | PKM | P14618 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9484312 | 1.00 | MAPT (0.63) | MAPTALDH1A1NPSR1KMT2AHTT | |
| SCHEMBL699995 | 0.85 | APP (0.50) | MAPTALDH1A1KMT2AHTTMEN1 | |
| SCHEMBL8799947 | 0.84 | ALDH1A1 (0.57) | MAPTALDH1A1NPSR1KMT2AHTT | |
| SCHEMBL31668287 | 0.79 | P2RX7 (0.47) | ALDH1A1NPSR1HTTCYP1A2CYP2C9 | |
| SCHEMBL9485766 | 0.78 | CA12 (0.41) | MAPTALDH1A1NPSR1KMT2AHTT | |
| SCHEMBL8986557 | 0.78 | ALDH1A1 (1.00) | MAPTALDH1A1NPSR1KMT2AHTT | |
| SCHEMBL8758840 | 0.78 | ALDH1A1 (1.00) | MAPTALDH1A1NPSR1KMT2AHTT | |
| SCHEMBL703149 | 0.76 | PLA2G2A (0.44) | ALDH1A1LMNAMAPK1APPSNCA | |
| SCHEMBL9485776 | 0.75 | ALDH1A1 (0.39) | MAPTALDH1A1NPSR1KMT2AHTT | |
| SCHEMBL1079929 | 0.75 | CHRM1 (0.48) | MAPTALDH1A1HTTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5272143-A | 6-oxoazepinoindole compounds, and pharmaceutical compositions containing them | KALI-CHEMIE PHARMA GMBH (DE) | 1993-12-21 | — | — | US | disclosed |