Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.31 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL948569 | 1.00 | NR1H2 (0.32) | NR1H2NR1H3CHEK2GPR119MEN1 | |
| SCHEMBL948843 | 0.84 | ESR2 (0.38) | NR1H2NR1H3GPR119MEN1KMT2A | |
| SCHEMBL948658 | 0.83 | S1PR1 (0.40) | — | |
| SCHEMBL948657 | 0.83 | S1PR1 (0.40) | — | |
| SCHEMBL949210 | 0.81 | S1PR1 (0.41) | — | |
| SCHEMBL949211 | 0.81 | S1PR1 (0.41) | — | |
| SCHEMBL949792 | 0.76 | S1PR1 (0.34) | — | |
| SCHEMBL3746518 | 0.73 | S1PR1 (0.40) | — | |
| SCHEMBL3401067 | 0.73 | S1PR1 (0.40) | — | |
| SCHEMBL948764 | 0.69 | S1PR1 (0.63) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011005295-A1 | MODULATORS OF THE SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | WO | disclosed |